MIAT promotes tumor-infiltrating CD8+ T-cell exhaustion and malignant progression of renal cell carcinoma via activating JAK3/STAT3 pathway

MIAT promotes tumor-infiltrating CD8+ T-cell exhaustion and malignant progression of renal cell carcinoma via activating JAK3/STAT3 pathway

Background The hyporesponsiveness of tumor-infiltrating exhausted CD8+ T cells to tumor cells contributes to immune escape of renal cell carcinoma (RCC), representing a major challenge in current immunotherapy. However, the underlying molecular mechanism of CD8+ T-cell exhaustion in the tumor microe...

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Main Authors: Bin Wang, Jian-Feng Wang, Jun-Hang Luo, Ming-xiao Zhang, Lan-yu Jing, Hao-tian Tan, Zi-ran Dai, Da-zhi Long, Han-chao Liu, An-ze Yu, Zi-yin Chen, Zhen-hua Chen
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/7/e011162.full
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