Th17 Cells in Autoimmune and Infectious Diseases
The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/651503 |
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| _version_ | 1832566876118450176 |
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| author | José Francisco Zambrano-Zaragoza Enrique Jhonatan Romo-Martínez Ma. de Jesús Durán-Avelar Noemí García-Magallanes Norberto Vibanco-Pérez |
| author_facet | José Francisco Zambrano-Zaragoza Enrique Jhonatan Romo-Martínez Ma. de Jesús Durán-Avelar Noemí García-Magallanes Norberto Vibanco-Pérez |
| author_sort | José Francisco Zambrano-Zaragoza |
| collection | DOAJ |
| description | The view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens. Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases. Also, they appear to be critical for controlling these disorders. Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation. Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23. The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review. |
| format | Article |
| id | doaj-art-056fdfed1eaf4cc7b6c102768bf765e3 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-056fdfed1eaf4cc7b6c102768bf765e32025-02-03T01:02:55ZengWileyInternational Journal of Inflammation2090-80402042-00992014-01-01201410.1155/2014/651503651503Th17 Cells in Autoimmune and Infectious DiseasesJosé Francisco Zambrano-Zaragoza0Enrique Jhonatan Romo-Martínez1Ma. de Jesús Durán-Avelar2Noemí García-Magallanes3Norberto Vibanco-Pérez4Universidad Autónoma de Nayarit, Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas, 63190 Tepic, NAY, MexicoUniversidad Politécnica de Sinaloa, Ingeniería en Biotecnología, 82199 Mazatlán, SIN, MexicoUniversidad Autónoma de Nayarit, Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas, 63190 Tepic, NAY, MexicoUniversidad Politécnica de Sinaloa, Ingeniería en Biotecnología, 82199 Mazatlán, SIN, MexicoUniversidad Autónoma de Nayarit, Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas, 63190 Tepic, NAY, MexicoThe view of CD4 T-cell-mediated immunity as a balance between distinct lineages of Th1 and Th2 cells has changed dramatically. Identification of the IL-17 family of cytokines and of the fact that IL-23 mediates the expansion of IL-17-producing T cells uncovered a new subset of Th cells designated Th17 cells, which have emerged as a third independent T-cell subset that may play an essential role in protection against certain extracellular pathogens. Moreover, Th17 cells have been extensively analyzed because of their strong association with inflammatory disorders and autoimmune diseases. Also, they appear to be critical for controlling these disorders. Similar to Th1 and Th2 cells, Th17 cells require specific cytokines and transcription factors for their differentiation. Th17 cells have been characterized as one of the major pathogenic Th cell populations underlying the development of many autoimmune diseases, and they are enhanced and stabilized by IL-23. The characteristics of Th17 cells, cytokines, and their sources, as well as their role in infectious and autoimmune diseases, are discussed in this review.http://dx.doi.org/10.1155/2014/651503 |
| spellingShingle | José Francisco Zambrano-Zaragoza Enrique Jhonatan Romo-Martínez Ma. de Jesús Durán-Avelar Noemí García-Magallanes Norberto Vibanco-Pérez Th17 Cells in Autoimmune and Infectious Diseases International Journal of Inflammation |
| title | Th17 Cells in Autoimmune and Infectious Diseases |
| title_full | Th17 Cells in Autoimmune and Infectious Diseases |
| title_fullStr | Th17 Cells in Autoimmune and Infectious Diseases |
| title_full_unstemmed | Th17 Cells in Autoimmune and Infectious Diseases |
| title_short | Th17 Cells in Autoimmune and Infectious Diseases |
| title_sort | th17 cells in autoimmune and infectious diseases |
| url | http://dx.doi.org/10.1155/2014/651503 |
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