Collagenase injection versus limited fasciectomy surgery to treat Dupuytren’s contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation

Collagenase injection versus limited fasciectomy surgery to treat Dupuytren’s contracture in adult patients in the UK: DISC, a non-inferiority RCT and economic evaluation

Background Dupuytren’s contracture is caused by nodules and cords which pull the fingers towards the palm of the hand. Treatments include limited fasciectomy surgery, collagenase injection and needle fasciotomy. There is limited evidence comparing limited fasciectomy with collagenase injection. Obje...

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Main Authors: Joseph Dias, Puvan Tharmanathan, Catherine Arundel, Charlie Welch, Qi Wu, Paul Leighton, Maria Armaou, Belen Corbacho, Nick Johnson, Sophie James, John Cooke, Christopher Bainbridge, Michael Craigen, David Warwick, Samantha Brady, Lydia Flett, Judy Jones, Catherine Knowlson, Michelle Watson, Ada Keding, Catherine Hewitt, David Torgerson
Format: Article
Language:English
Published: NIHR Journals Library 2024-12-01
Series:Health Technology Assessment
Subjects:
dupuytren contracture
collagenase clostridium histolyticum
limited fasciectomy
surgery
correction
randomised controlled trial
cost-effectiveness analysis
qualitative research
Online Access:https://doi.org/10.3310/KGXD8528
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https://doi.org/10.3310/KGXD8528

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