VCP regulates early tau seed amplification via specific cofactors

VCP regulates early tau seed amplification via specific cofactors

Abstract Background Neurodegenerative tauopathies may progress based on seeding by pathological tau assemblies, whereby an aggregate is released from one cell, gains entry to an adjacent or connected cell, and serves as a specific template for its own replication in the cytoplasm. Seeding into the c...

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Main Authors: Sushobhna Batra, Jaime Vaquer-Alicea, Clarissa Valdez, Skyler P. Taylor, Victor A. Manon, Anthony R. Vega, Omar M. Kashmer, Sourav Kolay, Andrew Lemoff, Nigel J. Cairns, Charles L. White, Marc I. Diamond
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Neurodegeneration
Subjects:
Tau
APEX2
VCP
p97
Cofactors
Disaggregase
Online Access:https://doi.org/10.1186/s13024-024-00783-z
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https://doi.org/10.1186/s13024-024-00783-z

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