Molecular Pathogenesis of MALT Lymphoma
Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT), also known as MALT lymphoma, which was first described in 1983 by Isaacson and Wright. MALT lymphomas arise at a wide range of different extranodal sites, with the...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/102656 |
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| author | Katharina Troppan Kerstin Wenzl Peter Neumeister Alexander Deutsch |
| author_facet | Katharina Troppan Kerstin Wenzl Peter Neumeister Alexander Deutsch |
| author_sort | Katharina Troppan |
| collection | DOAJ |
| description | Approximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT), also known as MALT lymphoma, which was first described in 1983 by Isaacson and Wright. MALT lymphomas arise at a wide range of different extranodal sites, with the highest frequency in the stomach, followed by lung, ocular adnexa, and thyroid, and with a low percentage in the small intestine. Interestingly, at least 3 different, apparently site-specific, chromosomal translocations and missense and frameshift mutations, all pathway-related genes affecting the NF-κB signal, have been implicated in the development and progression of MALT lymphoma. However, these genetic abnormalities alone are not sufficient for malignant transformation. There is now increasing evidence suggesting that the oncogenic product of translocation cooperates with immunological stimulation in oncogenesis, that is, the association with chronic bacterial infection or autoaggressive process. This review mainly discusses MALT lymphomas in terms of their genetic aberration and association with chronic infections and summarizes recent advances in their molecular pathogenesis. |
| format | Article |
| id | doaj-art-053f79c43dbe4863a4a700fa827b33cf |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-053f79c43dbe4863a4a700fa827b33cf2025-02-03T05:51:20ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/102656102656Molecular Pathogenesis of MALT LymphomaKatharina Troppan0Kerstin Wenzl1Peter Neumeister2Alexander Deutsch3Division of Hematology, Department of Internal Medicine, Medical University of Graz (MUG), 8036 Graz, AustriaDivision of Hematology, Department of Internal Medicine, Medical University of Graz (MUG), 8036 Graz, AustriaDivision of Hematology, Department of Internal Medicine, Medical University of Graz (MUG), 8036 Graz, AustriaDivision of Hematology, Department of Internal Medicine, Medical University of Graz (MUG), 8036 Graz, AustriaApproximately 8% of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT), also known as MALT lymphoma, which was first described in 1983 by Isaacson and Wright. MALT lymphomas arise at a wide range of different extranodal sites, with the highest frequency in the stomach, followed by lung, ocular adnexa, and thyroid, and with a low percentage in the small intestine. Interestingly, at least 3 different, apparently site-specific, chromosomal translocations and missense and frameshift mutations, all pathway-related genes affecting the NF-κB signal, have been implicated in the development and progression of MALT lymphoma. However, these genetic abnormalities alone are not sufficient for malignant transformation. There is now increasing evidence suggesting that the oncogenic product of translocation cooperates with immunological stimulation in oncogenesis, that is, the association with chronic bacterial infection or autoaggressive process. This review mainly discusses MALT lymphomas in terms of their genetic aberration and association with chronic infections and summarizes recent advances in their molecular pathogenesis.http://dx.doi.org/10.1155/2015/102656 |
| spellingShingle | Katharina Troppan Kerstin Wenzl Peter Neumeister Alexander Deutsch Molecular Pathogenesis of MALT Lymphoma Gastroenterology Research and Practice |
| title | Molecular Pathogenesis of MALT Lymphoma |
| title_full | Molecular Pathogenesis of MALT Lymphoma |
| title_fullStr | Molecular Pathogenesis of MALT Lymphoma |
| title_full_unstemmed | Molecular Pathogenesis of MALT Lymphoma |
| title_short | Molecular Pathogenesis of MALT Lymphoma |
| title_sort | molecular pathogenesis of malt lymphoma |
| url | http://dx.doi.org/10.1155/2015/102656 |
| work_keys_str_mv | AT katharinatroppan molecularpathogenesisofmaltlymphoma AT kerstinwenzl molecularpathogenesisofmaltlymphoma AT peterneumeister molecularpathogenesisofmaltlymphoma AT alexanderdeutsch molecularpathogenesisofmaltlymphoma |