Expression pattern of cancer-associated cellular senescence genes in clear cell renal cell carcinoma distinguishes tumor subclasses with clinical implications

Expression pattern of cancer-associated cellular senescence genes in clear cell renal cell carcinoma distinguishes tumor subclasses with clinical implications

Abstract Clear cell renal cell carcinoma (ccRCC) is a highly lethal subtype of renal cancer. Accumulating evidence suggests cellular senescence impacts tumor development and progression. This study aimed to identify ccRCC subtypes based on a cellular senescence gene signature and assess their clinic...

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Bibliographic Details
Main Authors: Zhongxu Zhu, Qi Cao, Jingyue Chen, Yiyang Sun, Fang Liu, Jiang Li, Miaomiao Tan
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Clear cell renal cell carcinoma (ccRCC)
Cellular senescence
Cancer subtypes
Tumor microenvironments
Therapy response
Online Access:https://doi.org/10.1038/s41598-024-84620-9
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https://doi.org/10.1038/s41598-024-84620-9

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