Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease

Pervasive glycative stress links metabolic imbalance and muscle atrophy in early-onset Parkinson's disease

Objective: Parkinson’s disease (PD) is recognized as a systemic condition, with clinical features potentially modifiable by dietary intervention. Diets high in saturated fats and refined sugars significantly increase PD risk and exacerbate motor and non-motor symptoms, yet precise metabolic mechanis...

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Main Authors: Natalia Prudente de Mello, Michelle Tamara Berger, Kim A. Lagerborg, Yingfei Yan, Jennifer Wettmarshausen, Susanne Keipert, Leopold Weidner, Janina Tokarz, Gabriele Möller, Stefano Ciciliot, Safal Walia, Yiming Cheng, Margarita Chudenkova, Anna Artati, Daniela Vogt Weisenhorn, Wolfgang Wurst, Jerzy Adamski, Roland Nilsson, Giovanni Cossu, Agnita Boon, Anneke Kievit, Wim Mandemakers, Vincenzo Bonifati, Mohit Jain, Martin Jastroch, Philippe Schmitt-Kopplin, Fabiana Perocchi, Kenneth Allen Dyar
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Molecular Metabolism
Subjects:
Parkinson's disease
Muscle atrophy
Glycobiology
Glycative stress
Advanced glycation endproducts (AGEs)
Biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000705
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