Deuterium metabolic imaging phenotypes mouse glioblastoma heterogeneity through glucose turnover kinetics

Deuterium metabolic imaging phenotypes mouse glioblastoma heterogeneity through glucose turnover kinetics

Glioblastomas are aggressive brain tumors with dismal prognosis. One of the main bottlenecks for developing more effective therapies for glioblastoma stems from their histologic and molecular heterogeneity, leading to distinct tumor microenvironments and disease phenotypes. Effectively characterizin...

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Bibliographic Details
Main Authors: Rui Vasco Simoes, Rafael Neto Henriques, Jonas L Olesen, Beatriz M Cardoso, Francisca F Fernandes, Mariana AV Monteiro, Sune N Jespersen, Tânia Carvalho, Noam Shemesh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-03-01
Series:eLife
Subjects:
deuterium metabolic imaging
glioblastoma
glycolysis
kinetic modeling
mitochondrial metabolism
Online Access:https://elifesciences.org/articles/100570
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https://elifesciences.org/articles/100570

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