The role of B cell-activating factor system in autoimmune diseases: mechanisms, disease implications, and therapeutic advances

The role of B cell-activating factor system in autoimmune diseases: mechanisms, disease implications, and therapeutic advances

The B cell-activating factor (BAFF) system, comprising two ligands and three receptors, plays a pivotal role in adaptive and innate immunity, driving autoimmunity through dysregulated B and T cell survival, differentiation, and cytokine production. This review synthesizes evidence linking BAFF syste...

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Bibliographic Details
Main Authors: Liang Li, Shengxian Shen, Shuai Shao, Erle Dang, Gang Wang, Hui Fang, Hongjiang Qiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
B cell-activating factor
autoimmune diseases
targeted therapies
autoimmunity
b cells
T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538555/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1538555/full

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