Sacha inchi (Plukenetia volubilis) seed oil alleviates Plasmodium berghei infection in mice by reducing proinflammatory cytokine levels and inhibiting parasite growth

Sacha inchi (Plukenetia volubilis) seed oil alleviates Plasmodium berghei infection in mice by reducing proinflammatory cytokine levels and inhibiting parasite growth

Abstract: Sacha inchi (Plukenetia volubilis) seed is a rich source of polyunsaturated fatty acids (PUFA), namely omega-3 and omega-6, which provide various health benefits, especially in the prevention of inflammatory diseases. Malaria, caused by Plasmodium species, triggers inflammasome activation...

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Main Authors: Rizky Setia Firdaus, Nadiah Farah Fadilah, Lucia Tri Suwanti, Heny Arwati, Heni Puspitasari
Format: Article
Language:English
Published: Tripoli University 2025-04-01
Series:Open Veterinary Journal
Subjects:
immunomodulatory
malaria
parasite growth
proinflammatory cytokines
sacha inchi seed oil
Online Access:http://www.ejmanager.com/fulltextpdf.php?mno=229630
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Summary:Abstract: Sacha inchi (Plukenetia volubilis) seed is a rich source of polyunsaturated fatty acids (PUFA), namely omega-3 and omega-6, which provide various health benefits, especially in the prevention of inflammatory diseases. Malaria, caused by Plasmodium species, triggers inflammasome activation, leading to the release of proinflammatory cytokines. Aim: This study aimed to reveal the immunomodulatory potential effect of Sacha inchi seed oil (SISO) on parasite growth and proinflammatory cytokine expression (Interleukin-6, Il-8, and Il-12) in Plasmodium berghei-infected mice. Methods: Twenty-five BALB/c mice were divided into five groups,including the control group (G1), infected and untreated group (G2), and three infected groups treated with SISO at doses of 250 mg/kg body weight (G3), 500 mg/kg body weight (G4), and 1000 mg/kg body weight (G5). Parasitemia levels were determined by calculating the percentage of infected red blood cells, whereas cytokine levels were measured using ELISA. Results: SISO treatment significantly reduced parasite growth in the 500 mg/kg body weight (18.12%) and 1000 mg/kg body weight (17.12%) groups compared with the untreated group (30.18%). Levels of Il-8 and Il-12 showed significant differences (p [Open Vet J 2025; 15(4.000): 1599-1606]
ISSN:2226-4485
2218-6050

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