Dysregulation of the Autophagy-Endolysosomal System in Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases

Amyotrophic lateral sclerosis (ALS) is a heterogeneous group of incurable motor neuron diseases (MNDs) characterized by a selective loss of upper and lower motor neurons in the brain and spinal cord. Most cases of ALS are sporadic, while approximately 5–10% cases are familial. More than 16 causative...

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Bibliographic Details
Main Authors: Asako Otomo, Lei Pan, Shinji Hadano
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Neurology Research International
Online Access:http://dx.doi.org/10.1155/2012/498428
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