Prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy: a retrospective study of 420 biopsy-proven cases
Background This retrospective study aims to investigate the prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy (HBV-MN).Methods Clinicopathologic and serologic records of 420 patients with histologically confirmed HBV-...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2313180 |
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| author | Haitao Lu Qianqian Xu Guming Zou Hongmei Gao Yue Yang Wenge Li Li Zhuo |
| author_facet | Haitao Lu Qianqian Xu Guming Zou Hongmei Gao Yue Yang Wenge Li Li Zhuo |
| author_sort | Haitao Lu |
| collection | DOAJ |
| description | Background This retrospective study aims to investigate the prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy (HBV-MN).Methods Clinicopathologic and serologic records of 420 patients with histologically confirmed HBV-MN between January 2014 and July 2021 were examined to determine the prevalence of seropositive and seronegative HBV-MN. Serum anti-PLA2R antibody testing was conducted on 280 patients with HBV-associated membranous nephropathy (HBV-MN) from August 2018 to July 2021. Immunopathologic characteristics of HBV-MN patients and anti-PLA2R antibody positivity were analyzed.Results Among 420 pathologically confirmed HBV-MN patients, 230 (54.8%) were seropositive for HBV. The seropositive group exhibited higher blood creatinine values and incidence of liver function abnormalities than the seronegative group (p < .05). Serum anti-PLA2R antibody testing on 280 HBV-MN patients revealed a total positive rate of 44.6%, with the seronegative group showing a significantly higher rate (62.6%) compared to the seropositive group (32.1%) (p < .01). The anti-PLA2R antibody-positive group displayed higher levels of urine protein (p < .05), serum cholesterol (p < .01), and IgG4 subtypes (p < .05) compared to the negative group. Additionally, the positive group had significantly lower levels of serum albumin and IgG than the negative group (p < .01).Conclusions This comprehensive study reveals a significantly higher prevalence of seronegative HBV-MN than previously thought. The blood creatinine values and incidence of liver function abnormalities was higher in the serology-positive group than in the serology-negative group. Notably, the seronegative group displayed a higher positive rate of anti-PLA2R antibodies compared to the seropositive group, indicating distinctive clinical and immunopathologic features. |
| format | Article |
| id | doaj-art-04d150c9cd9c457bbfb8db59639606c8 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-04d150c9cd9c457bbfb8db59639606c82025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2313180Prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy: a retrospective study of 420 biopsy-proven casesHaitao Lu0Qianqian Xu1Guming Zou2Hongmei Gao3Yue Yang4Wenge Li5Li Zhuo6Department of Nephrology, Friendship Hospital, Beijing, ChinaDepartment of Nephrology, Friendship Hospital, Beijing, ChinaDepartment of Nephrology, Friendship Hospital, Beijing, ChinaDepartment of Nephrology, Friendship Hospital, Beijing, ChinaDepartment of Nephrology, Friendship Hospital, Beijing, ChinaDepartment of Nephrology, Friendship Hospital, Beijing, ChinaDepartment of Nephrology, Friendship Hospital, Beijing, ChinaBackground This retrospective study aims to investigate the prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy (HBV-MN).Methods Clinicopathologic and serologic records of 420 patients with histologically confirmed HBV-MN between January 2014 and July 2021 were examined to determine the prevalence of seropositive and seronegative HBV-MN. Serum anti-PLA2R antibody testing was conducted on 280 patients with HBV-associated membranous nephropathy (HBV-MN) from August 2018 to July 2021. Immunopathologic characteristics of HBV-MN patients and anti-PLA2R antibody positivity were analyzed.Results Among 420 pathologically confirmed HBV-MN patients, 230 (54.8%) were seropositive for HBV. The seropositive group exhibited higher blood creatinine values and incidence of liver function abnormalities than the seronegative group (p < .05). Serum anti-PLA2R antibody testing on 280 HBV-MN patients revealed a total positive rate of 44.6%, with the seronegative group showing a significantly higher rate (62.6%) compared to the seropositive group (32.1%) (p < .01). The anti-PLA2R antibody-positive group displayed higher levels of urine protein (p < .05), serum cholesterol (p < .01), and IgG4 subtypes (p < .05) compared to the negative group. Additionally, the positive group had significantly lower levels of serum albumin and IgG than the negative group (p < .01).Conclusions This comprehensive study reveals a significantly higher prevalence of seronegative HBV-MN than previously thought. The blood creatinine values and incidence of liver function abnormalities was higher in the serology-positive group than in the serology-negative group. Notably, the seronegative group displayed a higher positive rate of anti-PLA2R antibodies compared to the seropositive group, indicating distinctive clinical and immunopathologic features.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2313180Hepatitis B virusHBV-associated membranous nephropathy (HBV-MN)seroprevalencemembranous nephropathy (MN)anti-phospholipase A2 receptor antibody |
| spellingShingle | Haitao Lu Qianqian Xu Guming Zou Hongmei Gao Yue Yang Wenge Li Li Zhuo Prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy: a retrospective study of 420 biopsy-proven cases Renal Failure Hepatitis B virus HBV-associated membranous nephropathy (HBV-MN) seroprevalence membranous nephropathy (MN) anti-phospholipase A2 receptor antibody |
| title | Prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy: a retrospective study of 420 biopsy-proven cases |
| title_full | Prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy: a retrospective study of 420 biopsy-proven cases |
| title_fullStr | Prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy: a retrospective study of 420 biopsy-proven cases |
| title_full_unstemmed | Prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy: a retrospective study of 420 biopsy-proven cases |
| title_short | Prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis B virus-associated membranous nephropathy: a retrospective study of 420 biopsy-proven cases |
| title_sort | prevalence and immunopathologic characteristics of seropositive and seronegative hepatitis b virus associated membranous nephropathy a retrospective study of 420 biopsy proven cases |
| topic | Hepatitis B virus HBV-associated membranous nephropathy (HBV-MN) seroprevalence membranous nephropathy (MN) anti-phospholipase A2 receptor antibody |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2313180 |
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