Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease

Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease

Abstract Background Fluoroethylnormemantine (FENM), a new Memantine (MEM) derivative, prevented amyloid-β[25–35] peptide (Aβ25–35)-induced neurotoxicity in mice, a pharmacological model of Alzheimer's disease (AD) with high predictive value for drug discovery. Here, as drug infusion is likely t...

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Main Authors: Allison Carles, Aline Freyssin, Sarra Guehairia, Thomas Reguero, Michel Vignes, Hélène Hirbec, Gilles Rubinstenn, Tangui Maurice
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Fluoroethylnormemantine (FENM)
Alzheimer's disease
Drug infusion
Neuroprotection
NMDA receptor expression
Online Access:https://doi.org/10.1186/s13195-024-01648-9
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https://doi.org/10.1186/s13195-024-01648-9

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