Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes
Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1,...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1994-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935194000050 |
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| _version_ | 1832562650061471744 |
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| author | J. M. Liebler S. L. Kunkel R. M. Allen M. D. Burdick R. M. Strieter |
| author_facet | J. M. Liebler S. L. Kunkel R. M. Allen M. D. Burdick R. M. Strieter |
| author_sort | J. M. Liebler |
| collection | DOAJ |
| description | Monocyte chemotactic protein (MCP-1) is a specific monocyte
chemoattractant and activating factor produced by both immune cells
(mononuclear phagocytes and lymphocytes) and non-immune cells
(parenchymal and stromal cells). In order to define the conditions
under which human monocytes express MCP-1, monocytes were exposed to
IFN-γ, IL- lβ, TNF-α, IL-4 or PHA under serum free
conditions. There was no significant MCP-1 production by monocytes
following exposure to IL-lβ, TNF-α or IL-4. In contrast,
stimulation with IFN-γ resulted in a dose dependent increase
in MCP-1 protein and mRNA expression. Simultaneous stimulation with
IFN-γ and IL-1β or TNF-α resulted in no further
increase in MCP-1 production. It is concluded that IFN-γ,
primarily a product of TH1 T lymphocytes, stimulates the expression
of MCP-1 by monocytes. |
| format | Article |
| id | doaj-art-048cbfb718784e44af635d52f9b5c970 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1994-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-048cbfb718784e44af635d52f9b5c9702025-02-03T01:22:02ZengWileyMediators of Inflammation0962-93511466-18611994-01-0131273110.1155/S0962935194000050Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by MonocytesJ. M. Liebler0S. L. Kunkel1R. M. Allen2M. D. Burdick3R. M. Strieter4Department of Medicine, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97201-3098, USADepartment of Pathology, University of Michigan, Medical School, Ann Arbor, Michigan, USADepartment of Pathology, University of Michigan, Medical School, Ann Arbor, Michigan, USADepartment of Pathology, University of Michigan, Medical School, Ann Arbor, Michigan, USADepartment of Internal Medicine, University of Michigan, Medical School, Ann Arbor, Michigan, USAMonocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1, monocytes were exposed to IFN-γ, IL- lβ, TNF-α, IL-4 or PHA under serum free conditions. There was no significant MCP-1 production by monocytes following exposure to IL-lβ, TNF-α or IL-4. In contrast, stimulation with IFN-γ resulted in a dose dependent increase in MCP-1 protein and mRNA expression. Simultaneous stimulation with IFN-γ and IL-1β or TNF-α resulted in no further increase in MCP-1 production. It is concluded that IFN-γ, primarily a product of TH1 T lymphocytes, stimulates the expression of MCP-1 by monocytes.http://dx.doi.org/10.1155/S0962935194000050 |
| spellingShingle | J. M. Liebler S. L. Kunkel R. M. Allen M. D. Burdick R. M. Strieter Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes Mediators of Inflammation |
| title | Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes |
| title_full | Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes |
| title_fullStr | Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes |
| title_full_unstemmed | Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes |
| title_short | Interferon-γ Stimulates Monocyte Chemotactic Protein-1 Expression by Monocytes |
| title_sort | interferon γ stimulates monocyte chemotactic protein 1 expression by monocytes |
| url | http://dx.doi.org/10.1155/S0962935194000050 |
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