Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases
HLA-G is a HLA-class Ib molecule with potent immunomodulatory activities, which is expressed in physiological conditions, where modulation of the immune response is required to avoid allograft recognition (i.e., maternal-fetal interface or transplanted patients). However, HLA-G can be expressed de n...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/4326495 |
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| author | Fabio Morandi Roberta Rizzo Enrico Fainardi Nathalie Rouas-Freiss Vito Pistoia |
| author_facet | Fabio Morandi Roberta Rizzo Enrico Fainardi Nathalie Rouas-Freiss Vito Pistoia |
| author_sort | Fabio Morandi |
| collection | DOAJ |
| description | HLA-G is a HLA-class Ib molecule with potent immunomodulatory activities, which is expressed in physiological conditions, where modulation of the immune response is required to avoid allograft recognition (i.e., maternal-fetal interface or transplanted patients). However, HLA-G can be expressed de novo at high levels in several pathological conditions, including solid and hematological tumors and during microbial or viral infections, leading to the impairment of the immune response against tumor cells or pathogens, respectively. On the other hand, the loss of HLA-G mediated control of the immune responses may lead to the onset of autoimmune/inflammatory diseases, caused by an uncontrolled activation of the immune effector cells. Here, we have reviewed novel findings on HLA-G functions in different physiological and pathological settings, which have been published in the last two years. These studies further confirmed the important role of this molecule in the modulation of the immune system. |
| format | Article |
| id | doaj-art-0438dabbc8a24f4f943893c584f8eb72 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-0438dabbc8a24f4f943893c584f8eb722025-02-03T06:01:03ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/43264954326495Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human DiseasesFabio Morandi0Roberta Rizzo1Enrico Fainardi2Nathalie Rouas-Freiss3Vito Pistoia4Laboratory of Oncology, Istituto Giannina Gaslini, 16147 Genoa, ItalyDepartment of Experimental and Diagnostic Medicine, Section of Microbiology, University of Ferrara, 44121 Ferrara, ItalyNeuroradiology Unit, Department of Diagnostic Imaging, Azienda Ospedaliero-Universitaria Careggi, 50134 Florence, ItalyCEA, Institut des Maladies Emergentes et des Therapies Innovantes (iMETI), Service de Recherche en Hemato-Immunologie (SRHI), Hôpital Saint-Louis, 75010 Paris, FranceLaboratory of Oncology, Istituto Giannina Gaslini, 16147 Genoa, ItalyHLA-G is a HLA-class Ib molecule with potent immunomodulatory activities, which is expressed in physiological conditions, where modulation of the immune response is required to avoid allograft recognition (i.e., maternal-fetal interface or transplanted patients). However, HLA-G can be expressed de novo at high levels in several pathological conditions, including solid and hematological tumors and during microbial or viral infections, leading to the impairment of the immune response against tumor cells or pathogens, respectively. On the other hand, the loss of HLA-G mediated control of the immune responses may lead to the onset of autoimmune/inflammatory diseases, caused by an uncontrolled activation of the immune effector cells. Here, we have reviewed novel findings on HLA-G functions in different physiological and pathological settings, which have been published in the last two years. These studies further confirmed the important role of this molecule in the modulation of the immune system.http://dx.doi.org/10.1155/2016/4326495 |
| spellingShingle | Fabio Morandi Roberta Rizzo Enrico Fainardi Nathalie Rouas-Freiss Vito Pistoia Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases Journal of Immunology Research |
| title | Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases |
| title_full | Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases |
| title_fullStr | Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases |
| title_full_unstemmed | Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases |
| title_short | Recent Advances in Our Understanding of HLA-G Biology: Lessons from a Wide Spectrum of Human Diseases |
| title_sort | recent advances in our understanding of hla g biology lessons from a wide spectrum of human diseases |
| url | http://dx.doi.org/10.1155/2016/4326495 |
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