Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds.
The imidazo[2,1-b]thiazole-5-carboxamides (ITAs) are a promising class of anti-tuberculosis agents shown to have potent activity in vitro and to target QcrB, a key component of the mycobacterial cytochrome bcc-aa3 super complex critical for the electron transport chain. Herein we report the intracel...
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| Main Authors: | Garrett C Moraski, Nathalie Deboosère, Kate L Marshall, Heath A Weaver, Alexandre Vandeputte, Courtney Hastings, Lisa Woolhiser, Anne J Lenaerts, Priscille Brodin, Marvin J Miller |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227224&type=printable |
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