Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds.

Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds.

The imidazo[2,1-b]thiazole-5-carboxamides (ITAs) are a promising class of anti-tuberculosis agents shown to have potent activity in vitro and to target QcrB, a key component of the mycobacterial cytochrome bcc-aa3 super complex critical for the electron transport chain. Herein we report the intracel...

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Main Authors: Garrett C Moraski, Nathalie Deboosère, Kate L Marshall, Heath A Weaver, Alexandre Vandeputte, Courtney Hastings, Lisa Woolhiser, Anne J Lenaerts, Priscille Brodin, Marvin J Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227224&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0227224&type=printable

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