Five New Indole Alkaloid Derivatives from Deep-Sea Fungus <i>Aspergillus fumigatus</i> AF1
One new gliotoxin derivative fumianthrogliotoxin (<b>1</b>), one new indoquizoline alkaloid <i>N</i>3-(methyl propionate) indoquizoline (<b>2</b>), and three novel indole alkaloids, anthroxyindole (<b>3</b>), (±)-asperfumiindole A (<b>4</b>...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/23/1/4 |
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| Summary: | One new gliotoxin derivative fumianthrogliotoxin (<b>1</b>), one new indoquizoline alkaloid <i>N</i>3-(methyl propionate) indoquizoline (<b>2</b>), and three novel indole alkaloids, anthroxyindole (<b>3</b>), (±)-asperfumiindole A (<b>4</b>), and (±)-asperfumiindole B (<b>5</b>), together with 16 known compounds (<b>6</b>–<b>21</b>), were isolated from the culture of deep-sea derived fungus <i>Aspergillus fumigatus</i> AF1. Their chemical structures and absolute configurations were determined through the analysis of NMR data in combination with electronic circular dichroism (ECD) calculations and other spectroscopic analyses. Compounds <b>2</b>–<b>11</b> and <b>13</b>–<b>21</b> were evaluated for anti-pulmonary fibrosis activity. Compounds <b>8</b> and <b>13</b> displayed significant downregulation of the mRNA expression levels of all three molecular markers (COL1A1, α-SMA and FN1), with compound <b>13</b> exhibiting the best performance among all the tested compounds. |
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| ISSN: | 1660-3397 |