Generation of live mice from haploid ESCs with germline-DMR deletions or switch

Generation of live mice from haploid ESCs with germline-DMR deletions or switch

Abstract Genomic imprinting is required for sexual reproduction and embryonic development of mammals, in which, differentially methylated regions (DMRs) regulate the parent-specific monoallelic expression of imprinted genes. Numerous studies on imprinted genes have highlighted their critical roles i...

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Bibliographic Details
Main Authors: Yongjian Ma, Meng Yan, Zhenfei Xie, Hongling Zhang, Zhoujie Li, Yuanyuan Li, Suming Yang, Meiling Zhang, Wen Li, Jinsong Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Cell Discovery
Online Access:https://doi.org/10.1038/s41421-024-00757-x
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