Chlorambucil-Induced Acute Interstitial Pneumonitis
Chlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL. The interstitial pneumonitis responded to therap...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2014/575417 |
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| author | Hammad Shafqat Adam J. Olszewski |
| author_facet | Hammad Shafqat Adam J. Olszewski |
| author_sort | Hammad Shafqat |
| collection | DOAJ |
| description | Chlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL. The interstitial pneumonitis responded to therapy with prednisone. We performed a systematic review of literature and identified 13 other case reports of chlorambucil-induced pulmonary toxicity, particularly interstitial pneumonitis. No unifying risk factor could be discerned and the mechanism of injury remains unknown. In contrast, major randomized trials of chlorambucil therapy in CLL have not reported interstitial pneumonitis as an adverse effect, which may be due to the rarity of the phenomenon or due to underreporting of events occurring after completion of treatment. Clinicians should consider drug-induced interstitial pneumonitis in the differential diagnosis of a suggestive syndrome developing even after discontinuation of chlorambucil. |
| format | Article |
| id | doaj-art-0403d14c728247a891ac3f88f2af45d1 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-0403d14c728247a891ac3f88f2af45d12025-02-03T05:59:15ZengWileyCase Reports in Hematology2090-65602090-65792014-01-01201410.1155/2014/575417575417Chlorambucil-Induced Acute Interstitial PneumonitisHammad Shafqat0Adam J. Olszewski1Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860, USAMemorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860, USAChlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL. The interstitial pneumonitis responded to therapy with prednisone. We performed a systematic review of literature and identified 13 other case reports of chlorambucil-induced pulmonary toxicity, particularly interstitial pneumonitis. No unifying risk factor could be discerned and the mechanism of injury remains unknown. In contrast, major randomized trials of chlorambucil therapy in CLL have not reported interstitial pneumonitis as an adverse effect, which may be due to the rarity of the phenomenon or due to underreporting of events occurring after completion of treatment. Clinicians should consider drug-induced interstitial pneumonitis in the differential diagnosis of a suggestive syndrome developing even after discontinuation of chlorambucil.http://dx.doi.org/10.1155/2014/575417 |
| spellingShingle | Hammad Shafqat Adam J. Olszewski Chlorambucil-Induced Acute Interstitial Pneumonitis Case Reports in Hematology |
| title | Chlorambucil-Induced Acute Interstitial Pneumonitis |
| title_full | Chlorambucil-Induced Acute Interstitial Pneumonitis |
| title_fullStr | Chlorambucil-Induced Acute Interstitial Pneumonitis |
| title_full_unstemmed | Chlorambucil-Induced Acute Interstitial Pneumonitis |
| title_short | Chlorambucil-Induced Acute Interstitial Pneumonitis |
| title_sort | chlorambucil induced acute interstitial pneumonitis |
| url | http://dx.doi.org/10.1155/2014/575417 |
| work_keys_str_mv | AT hammadshafqat chlorambucilinducedacuteinterstitialpneumonitis AT adamjolszewski chlorambucilinducedacuteinterstitialpneumonitis |