Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration
While small bone defects heal spontaneously, large bone defects need surgical intervention for bone transplantation. Autologous bone grafts are the best and safest strategy for bone repair. An alternative method is to use allogenic bone graft. Both methods have limitations, particularly when bone d...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/980353 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550184550137856 |
|---|---|
| author | Elham Zomorodian Mohamadreza Baghaban Eslaminejad |
| author_facet | Elham Zomorodian Mohamadreza Baghaban Eslaminejad |
| author_sort | Elham Zomorodian |
| collection | DOAJ |
| description | While small bone defects heal spontaneously, large bone defects need surgical intervention for bone transplantation. Autologous bone grafts are the best and safest strategy for bone repair. An alternative method is to use allogenic bone graft. Both methods have limitations, particularly when bone defects are of a critical size. In these cases, bone constructs created by tissue engineering technologies are of utmost importance. Cells are one main component in the manufacture of bone construct. A few cell types, including embryonic stem cells (ESCs), adult osteoblast, and adult stem cells, can be used for this purpose. Mesenchymal stem cells (MSCs), as adult stem cells, possess characteristics that make them good candidate for bone repair. This paper discusses different aspects of MSCs that render them an appropriate cell type for clinical use to promote bone regeneration. |
| format | Article |
| id | doaj-art-04009b6ecf4e47ab84fd9fbf331d178d |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-04009b6ecf4e47ab84fd9fbf331d178d2025-02-03T06:07:28ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/980353980353Mesenchymal Stem Cells as a Potent Cell Source for Bone RegenerationElham Zomorodian0Mohamadreza Baghaban Eslaminejad1Department of Stem Cell and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, 1665659911 Tehran, IranDepartment of Stem Cell and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, 1665659911 Tehran, IranWhile small bone defects heal spontaneously, large bone defects need surgical intervention for bone transplantation. Autologous bone grafts are the best and safest strategy for bone repair. An alternative method is to use allogenic bone graft. Both methods have limitations, particularly when bone defects are of a critical size. In these cases, bone constructs created by tissue engineering technologies are of utmost importance. Cells are one main component in the manufacture of bone construct. A few cell types, including embryonic stem cells (ESCs), adult osteoblast, and adult stem cells, can be used for this purpose. Mesenchymal stem cells (MSCs), as adult stem cells, possess characteristics that make them good candidate for bone repair. This paper discusses different aspects of MSCs that render them an appropriate cell type for clinical use to promote bone regeneration.http://dx.doi.org/10.1155/2012/980353 |
| spellingShingle | Elham Zomorodian Mohamadreza Baghaban Eslaminejad Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration Stem Cells International |
| title | Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration |
| title_full | Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration |
| title_fullStr | Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration |
| title_full_unstemmed | Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration |
| title_short | Mesenchymal Stem Cells as a Potent Cell Source for Bone Regeneration |
| title_sort | mesenchymal stem cells as a potent cell source for bone regeneration |
| url | http://dx.doi.org/10.1155/2012/980353 |
| work_keys_str_mv | AT elhamzomorodian mesenchymalstemcellsasapotentcellsourceforboneregeneration AT mohamadrezabaghabaneslaminejad mesenchymalstemcellsasapotentcellsourceforboneregeneration |