Effect of fibroblast heterogeneity on prognosis and drug resistance in high-grade serous ovarian cancer

Effect of fibroblast heterogeneity on prognosis and drug resistance in high-grade serous ovarian cancer

Abstract Tumor heterogeneity is associated with poor prognosis and drug resistance, leading to therapeutic failure. Here, we used tumor evolution analysis to determine the intra- and intertumoral heterogeneity of high-grade serous ovarian cancer (HGSOC) and analyze the correlation between tumor hete...

Full description

Saved in:
Bibliographic Details
Main Authors: Tingjie Wang, Lingxi Tian, Bing Wei, Jun Li, Cuiyun Zhang, Ruitao Long, Xiaofei Zhu, Yougai Zhang, Bo Wang, Guangbo Tang, Jun Yang, Yongjun Guo
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Tumor cell state
functional clonality
tumor evolution
HGSOC
tumor transcriptomic heterogeneity
microenvironment
Online Access:https://doi.org/10.1038/s41598-024-77630-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-024-77630-0

Similar Items