Causal relationship between gastroesophageal reflux disease and chronic obstructive respiratory disease: A bidirectional Mendelian randomization study
Background: Numerous observational studies have posited that gastroesophageal reflux disease (GERD) might amplify the risk of chronic airway conditions such as chronic obstructive pulmonary disease (COPD) and asthma. Yet, a definitive causal link remains to be established. To this end, we utilized a...
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Elsevier
2025-01-01
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| author | Shan Lin Dingfeng Lai Wanmei He Qingyuan Zhan |
| author_facet | Shan Lin Dingfeng Lai Wanmei He Qingyuan Zhan |
| author_sort | Shan Lin |
| collection | DOAJ |
| description | Background: Numerous observational studies have posited that gastroesophageal reflux disease (GERD) might amplify the risk of chronic airway conditions such as chronic obstructive pulmonary disease (COPD) and asthma. Yet, a definitive causal link remains to be established. To this end, we utilized a two-sample Mendelian randomization approach (MR) to investigate the potential causal dynamics between GERD and these chronic obstructive respiratory diseases. Methods: Using a two-sample bidirectional MR, we explored the causal influence of GERD on the risks of developing COPD and asthma, drawing on aggregated genome-wide association study data from European cohorts. Results: Our analysis elucidated a notable causal relationship, with individuals genetically inclined towards GERD exhibiting a significantly elevated propensity to develop COPD (odds ratio [OR] = 1.520, 95 % confidence interval [CI] 1.376−1.680, P = 2.173 × 10−16) and asthma (OR = 1.420, 95 % CI 1.340−1.504, P = 1.269 × 10−32). The absence of heterogeneity and pleiotropy was confirmed through the Cochran Q test, funnel plots, MR-Egger intercept test, and MR-PRESSO. Directional causality was further substantiated by Steiger testing. Conversely, reverse MR analyses did not identify a significant causal pathway between COPD or asthma and GERD onset. Conclusion: This investigation substantiates a robust positive correlation between GERD and increased risks for COPD and asthma, laying a foundational basis for incorporating GERD management into preventive and therapeutic strategies for these chronic obstructive respiratory diseases. |
| format | Article |
| id | doaj-art-03d499181ca34e3989a4406f34f351cc |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| spelling | doaj-art-03d499181ca34e3989a4406f34f351cc2025-02-02T05:28:59ZengElsevierHeliyon2405-84402025-01-01112e42100Causal relationship between gastroesophageal reflux disease and chronic obstructive respiratory disease: A bidirectional Mendelian randomization studyShan Lin0Dingfeng Lai1Wanmei He2Qingyuan Zhan3Department of Respiratory and Critical Care Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China; Corresponding author.Department of Medical Intensive Care Unit, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, ChinaDepartment of Medical Intensive Care Unit, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, 510080, ChinaDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Center for Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; Corresponding author.drzhanqy@163.comBackground: Numerous observational studies have posited that gastroesophageal reflux disease (GERD) might amplify the risk of chronic airway conditions such as chronic obstructive pulmonary disease (COPD) and asthma. Yet, a definitive causal link remains to be established. To this end, we utilized a two-sample Mendelian randomization approach (MR) to investigate the potential causal dynamics between GERD and these chronic obstructive respiratory diseases. Methods: Using a two-sample bidirectional MR, we explored the causal influence of GERD on the risks of developing COPD and asthma, drawing on aggregated genome-wide association study data from European cohorts. Results: Our analysis elucidated a notable causal relationship, with individuals genetically inclined towards GERD exhibiting a significantly elevated propensity to develop COPD (odds ratio [OR] = 1.520, 95 % confidence interval [CI] 1.376−1.680, P = 2.173 × 10−16) and asthma (OR = 1.420, 95 % CI 1.340−1.504, P = 1.269 × 10−32). The absence of heterogeneity and pleiotropy was confirmed through the Cochran Q test, funnel plots, MR-Egger intercept test, and MR-PRESSO. Directional causality was further substantiated by Steiger testing. Conversely, reverse MR analyses did not identify a significant causal pathway between COPD or asthma and GERD onset. Conclusion: This investigation substantiates a robust positive correlation between GERD and increased risks for COPD and asthma, laying a foundational basis for incorporating GERD management into preventive and therapeutic strategies for these chronic obstructive respiratory diseases.http://www.sciencedirect.com/science/article/pii/S2405844025004803GERDCOPDAsthmaCausality |
| spellingShingle | Shan Lin Dingfeng Lai Wanmei He Qingyuan Zhan Causal relationship between gastroesophageal reflux disease and chronic obstructive respiratory disease: A bidirectional Mendelian randomization study Heliyon GERD COPD Asthma Causality |
| title | Causal relationship between gastroesophageal reflux disease and chronic obstructive respiratory disease: A bidirectional Mendelian randomization study |
| title_full | Causal relationship between gastroesophageal reflux disease and chronic obstructive respiratory disease: A bidirectional Mendelian randomization study |
| title_fullStr | Causal relationship between gastroesophageal reflux disease and chronic obstructive respiratory disease: A bidirectional Mendelian randomization study |
| title_full_unstemmed | Causal relationship between gastroesophageal reflux disease and chronic obstructive respiratory disease: A bidirectional Mendelian randomization study |
| title_short | Causal relationship between gastroesophageal reflux disease and chronic obstructive respiratory disease: A bidirectional Mendelian randomization study |
| title_sort | causal relationship between gastroesophageal reflux disease and chronic obstructive respiratory disease a bidirectional mendelian randomization study |
| topic | GERD COPD Asthma Causality |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025004803 |
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