Restoration effect of chemically modified microRNA-143-3p on acute myocardial infarction in animal models

Restoration effect of chemically modified microRNA-143-3p on acute myocardial infarction in animal models

Abstract We investigated whether miR143#12, a synthesized chemically modified miR-143-3p derivative, exerts therapeutic effects on acute myocardial infarction (AMI). Sprague–Dawley rats and Japanese white rabbits underwent 30 min of coronary occlusion followed by 2 weeks of reperfusion. The rat AMI...

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Bibliographic Details
Main Authors: Shingo Minatoguchi, Nobuhiko Sugito, Kazuki Heishima, Yuko Ito, Remi Nakashima, Hiroyuki Okura, Yukihiro Akao, Shinya Minatoguchi
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Chemically modified miR143
Myocardial infarction
Infarct size
Cardiac function
Autophagic cell death
Angiogenesis
Online Access:https://doi.org/10.1038/s41598-024-76429-3
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https://doi.org/10.1038/s41598-024-76429-3

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