Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis

Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis

Abstract Objectives Leflunomide (LEF) is a conventional synthetic disease-modifying antirheumatic drug and suppresses T-cell proliferation and activity by inhibiting pyrimidine synthesis using dihydroorotase dehydrogenase (DHODH); however, several studies have demonstrated that LEF possesses antican...

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Main Authors: Chieko Niwata, Takayuki Nakagawa, Takako Naruse, Miyuki Sakuma, Nao Yamakado, Misaki Akagi, Shigehiro Ono, Kei Tobiume, Jing Gao, Eijiro Jimi, Kouji Ohta, Tomonao Aikawa
Format: Article
Language:English
Published: Springer 2025-01-01
Series:Discover Oncology
Subjects:
Leflunomide
Oral squamous cell carcinoma
Syngeneic mice
Drug repositioning
Online Access:https://doi.org/10.1007/s12672-025-01763-5
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https://doi.org/10.1007/s12672-025-01763-5

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