Rapid access to diverse indoles by addition/SNAr with Grignard reagents and 2-fluorophenyl acetonitriles

Rapid access to diverse indoles by addition/SNAr with Grignard reagents and 2-fluorophenyl acetonitriles

Indoles are essential heterocycles in natural products, biological chemistry, and medicinal chemistry. Efficient approaches to their synthesis, therefore, remain in demand. Herein is reported a novel and scalable method to produce a wide variety of indoles by combining Grignard reagents and 2-fluoro...

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Bibliographic Details
Main Authors: Yuanyun Gu, Yaxin Feng, Baotong Huang, Yan-En Wang, Yaqi Yuan, Dan Xiong, Yonghong Hu, Xiufang Xu, Patrick J. Walsh, Jianyou Mao
Format: Article
Language:English
Published: KeAi Communications Co. Ltd. 2025-05-01
Series:Green Synthesis and Catalysis
Subjects:
2-Aryl indoles
Grignard reagents
2-Fluorobenzyl cyanides
SNAr
Indomethacin
Online Access:http://www.sciencedirect.com/science/article/pii/S2666554924000243
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http://www.sciencedirect.com/science/article/pii/S2666554924000243

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