Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

Collagen-I fibrillogenesis is crucial to health and development, where dysregulation is a hallmark of fibroproliferative diseases. Here, we show that collagen-I fibril assembly required a functional endocytic system that recycles collagen-I to assemble new fibrils. Endogenous collagen production was...

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Bibliographic Details
Main Authors: Joan Chang, Adam Pickard, Jeremy A Herrera, Sarah O'Keefe, Richa Garva, Matthew Hartshorn, Anna Hoyle, Lewis Dingle, John Knox, Thomas A Jowitt, Madeleine Coy, Jason Wong, Adam Reid, Yinhui Lu, Cédric Zeltz, Rajamiyer V Venkateswaran, Patrick T Caswell, Stephen High, Donald Gullberg, Karl E Kadler
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-01-01
Series:eLife
Subjects:
collagen
fibrosis
endocytosis
integrin
fibrillogenesis
Online Access:https://elifesciences.org/articles/95842
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https://elifesciences.org/articles/95842

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