Metformin-Associated Acute Kidney Injury and Lactic Acidosis
Objectives. Metformin is the preferred oral antidiabetic agent for type 2 diabetes. Lactic acidosis is described as a rare complication, usually during an acute kidney injury (AKI). Material and Methods. We conducted a prospective observational study of metformin-associated AKI cases during four yea...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/749653 |
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| _version_ | 1832552060732571648 |
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| author | David Arroyo Rosa Melero Nayara Panizo Marian Goicoechea Patrocinio Rodríguez-Benítez Soledad García Vinuesa Eduardo Verde Alberto Tejedor José Luño |
| author_facet | David Arroyo Rosa Melero Nayara Panizo Marian Goicoechea Patrocinio Rodríguez-Benítez Soledad García Vinuesa Eduardo Verde Alberto Tejedor José Luño |
| author_sort | David Arroyo |
| collection | DOAJ |
| description | Objectives. Metformin is the preferred oral antidiabetic agent for type 2 diabetes. Lactic acidosis is described as a rare complication, usually during an acute kidney injury (AKI). Material and Methods. We conducted a prospective observational study of metformin-associated AKI cases during four years. 29 cases were identified. Previous renal function, clinical data, and outcomes were recorded. Results. An episode of acute gastroenteritis precipitated the event in 26 cases. Three developed a septic shock. Three patients died, the only related factor being liver dysfunction. More severe metabolic acidosis hyperkalemia and anemia were associated with higher probabilities of RRT requirement. We could not find any relationship between previous renal dysfunction and the outcome of the AKI. Conclusions. AKI associated to an episode of volume depletion due to gastrointestinal losses is a serious complication in type 2 diabetic patients on metformin. Previous renal dysfunction (mild-to-moderate CKD) has no influence on the severity or outcome. |
| format | Article |
| id | doaj-art-02d59e94c56343dbbf4277f6fca77b6b |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-02d59e94c56343dbbf4277f6fca77b6b2025-02-03T05:59:37ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/749653749653Metformin-Associated Acute Kidney Injury and Lactic AcidosisDavid Arroyo0Rosa Melero1Nayara Panizo2Marian Goicoechea3Patrocinio Rodríguez-Benítez4Soledad García Vinuesa5Eduardo Verde6Alberto Tejedor7José Luño8Nephrology Department, Hospital General Universitario Gregorio Marañón, Street Dr. Esquerdo 46, 28007 Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Street Dr. Esquerdo 46, 28007 Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Street Dr. Esquerdo 46, 28007 Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Street Dr. Esquerdo 46, 28007 Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Street Dr. Esquerdo 46, 28007 Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Street Dr. Esquerdo 46, 28007 Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Street Dr. Esquerdo 46, 28007 Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Street Dr. Esquerdo 46, 28007 Madrid, SpainNephrology Department, Hospital General Universitario Gregorio Marañón, Street Dr. Esquerdo 46, 28007 Madrid, SpainObjectives. Metformin is the preferred oral antidiabetic agent for type 2 diabetes. Lactic acidosis is described as a rare complication, usually during an acute kidney injury (AKI). Material and Methods. We conducted a prospective observational study of metformin-associated AKI cases during four years. 29 cases were identified. Previous renal function, clinical data, and outcomes were recorded. Results. An episode of acute gastroenteritis precipitated the event in 26 cases. Three developed a septic shock. Three patients died, the only related factor being liver dysfunction. More severe metabolic acidosis hyperkalemia and anemia were associated with higher probabilities of RRT requirement. We could not find any relationship between previous renal dysfunction and the outcome of the AKI. Conclusions. AKI associated to an episode of volume depletion due to gastrointestinal losses is a serious complication in type 2 diabetic patients on metformin. Previous renal dysfunction (mild-to-moderate CKD) has no influence on the severity or outcome.http://dx.doi.org/10.4061/2011/749653 |
| spellingShingle | David Arroyo Rosa Melero Nayara Panizo Marian Goicoechea Patrocinio Rodríguez-Benítez Soledad García Vinuesa Eduardo Verde Alberto Tejedor José Luño Metformin-Associated Acute Kidney Injury and Lactic Acidosis International Journal of Nephrology |
| title | Metformin-Associated Acute Kidney Injury and Lactic Acidosis |
| title_full | Metformin-Associated Acute Kidney Injury and Lactic Acidosis |
| title_fullStr | Metformin-Associated Acute Kidney Injury and Lactic Acidosis |
| title_full_unstemmed | Metformin-Associated Acute Kidney Injury and Lactic Acidosis |
| title_short | Metformin-Associated Acute Kidney Injury and Lactic Acidosis |
| title_sort | metformin associated acute kidney injury and lactic acidosis |
| url | http://dx.doi.org/10.4061/2011/749653 |
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