Rapid inference of antibiotic susceptibility phenotype of uropathogens using metagenomic sequencing with neighbor typing

Rapid inference of antibiotic susceptibility phenotype of uropathogens using metagenomic sequencing with neighbor typing

ABSTRACT Timely diagnostic tools are needed to improve antibiotic treatment. Pairing metagenomic sequencing with genomic neighbor typing algorithms may support rapid clinically actionable results. We created resistance-associated sequence elements (RASE) databases for Escherichia coli and Klebsiella...

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Main Authors: Amanda C. Carroll, Leanne Mortimer, Hiren Ghosh, Sandra Reuter, Hajo Grundmann, Karel Brinda, William P. Hanage, Angel Li, Aimee Paterson, Andrew Purssell, Ashley Rooney, Noelle R. Yee, Bryan Coburn, Shola Able-Thomas, Martin Antonio, Allison McGeer, Derek R. MacFadden
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:Microbiology Spectrum
Subjects:
antimicrobial resistance
metagenomics
nanopore
rapid diagnostics
genomics
urinary tract infection
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01366-24
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https://journals.asm.org/doi/10.1128/spectrum.01366-24

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