Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis
A protein named AAH was isolated from the bacterium Microbacterium arborescens SE14, a gut commensal of the lepidopteran larvae. It showed not only a high sequence similarity to Dps-like proteins (DNA-binding proteins from starved cell) but also reversible hydrolase activity. A comparative genomic a...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/504905 |
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| author | Liyan Ping Matthias Platzer Gaiping Wen Nicolas Delaroque |
| author_facet | Liyan Ping Matthias Platzer Gaiping Wen Nicolas Delaroque |
| author_sort | Liyan Ping |
| collection | DOAJ |
| description | A protein named AAH was isolated from the bacterium Microbacterium arborescens SE14, a gut commensal of the lepidopteran larvae. It showed not only a high sequence similarity to Dps-like proteins (DNA-binding proteins from starved cell) but also reversible hydrolase activity. A comparative genomic analysis was performed to gain more insights into its evolution. The GC profile of the aah gene indicated that it was evolved from a low GC ancestor. Its stop codon usage was also different from the general pattern of Actinobacterial genomes. The phylogeny of dps-like proteins showed strong correlation with the phylogeny of host bacteria. A conserved genomic synteny was identified in some taxonomically related Actinobacteria, suggesting that the ancestor genes had incorporated into the genome before the divergence of Micrococcineae from other families. The aah gene had evolved new function but still retained the typical dodecameric structure. |
| format | Article |
| id | doaj-art-02c6765b713047a895eea10fa3344c64 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-02c6765b713047a895eea10fa3344c642025-02-03T06:06:58ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/504905504905Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic AnalysisLiyan Ping0Matthias Platzer1Gaiping Wen2Nicolas Delaroque3Department of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 8, 07745 Jena, GermanyGenome Analysis, Leibniz Institute for Age Research-Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena, GermanyGenome Analysis, Leibniz Institute for Age Research-Fritz Lipmann Institute, Beutenbergstraße 11, 07745 Jena, GermanyDepartment of Bioorganic Chemistry, Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 8, 07745 Jena, GermanyA protein named AAH was isolated from the bacterium Microbacterium arborescens SE14, a gut commensal of the lepidopteran larvae. It showed not only a high sequence similarity to Dps-like proteins (DNA-binding proteins from starved cell) but also reversible hydrolase activity. A comparative genomic analysis was performed to gain more insights into its evolution. The GC profile of the aah gene indicated that it was evolved from a low GC ancestor. Its stop codon usage was also different from the general pattern of Actinobacterial genomes. The phylogeny of dps-like proteins showed strong correlation with the phylogeny of host bacteria. A conserved genomic synteny was identified in some taxonomically related Actinobacteria, suggesting that the ancestor genes had incorporated into the genome before the divergence of Micrococcineae from other families. The aah gene had evolved new function but still retained the typical dodecameric structure.http://dx.doi.org/10.1100/2012/504905 |
| spellingShingle | Liyan Ping Matthias Platzer Gaiping Wen Nicolas Delaroque Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis The Scientific World Journal |
| title | Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis |
| title_full | Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis |
| title_fullStr | Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis |
| title_full_unstemmed | Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis |
| title_short | Coevolution of aah: A dps-Like Gene with the Host Bacterium Revealed by Comparative Genomic Analysis |
| title_sort | coevolution of aah a dps like gene with the host bacterium revealed by comparative genomic analysis |
| url | http://dx.doi.org/10.1100/2012/504905 |
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