Understanding Epistatic Interactions between Genes Targeted by Non-coding Regulatory Elements in Complex Diseases

Understanding Epistatic Interactions between Genes Targeted by Non-coding Regulatory Elements in Complex Diseases

Genome-wide association studies have proven the highly polygenic architecture of complex diseases or traits; therefore, single-locus-based methods are usually unable to detect all involved loci, especially when individual loci exert small effects. Moreover, the majority of associated single-nucleoti...

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Bibliographic Details
Main Authors: Min Kyung Sung, Hyoeun Bang, Jung Kyoon Choi
Format: Article
Language:English
Published: BioMed Central 2014-12-01
Series:Genomics & Informatics
Subjects:
coronary artery disease
diabetes mellitus
epistasis
hypertension
regulatory region
Online Access:http://genominfo.org/upload/pdf/gni-12-181.pdf
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http://genominfo.org/upload/pdf/gni-12-181.pdf

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