Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors

Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors

Fluorine substituted 1,2,4-triazinones have been synthesized via alkylation, amination, and/or oxidation of 6-(2-amino-5-fluorophenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one 1 and 4-fluoro-N-(4-fluoro-2-(5-oxo-3-thioxo-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl)phenyl)benzamide 5 as possible anti-H...

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Bibliographic Details
Main Authors: Mohammed S. I. Makki, Reda M. Abdel-Rahman, Khalid A. Khan
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2014/430573
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