Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Colitis in Mice via the Modulation of NF-κB and Nrf2/HO-1 Pathways

Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Colitis in Mice via the Modulation of NF-κB and Nrf2/HO-1 Pathways

Conclusion: MGQD alleviated UC by suppressing inflammation and oxidative stress via the modulation of NF-κB and Nrf2/HO-1 pathways, suggesting that MGQD may be a candidate therapy for UC.

Saved in:

Bibliographic Details
Main Authors:	Jinke Huang, Jiaqi Zhang, Zhihong Liu, Jing Ma, Yifan Wang, Fengyun Wang, Xudong Tang
Format:	Article
Language:	English
Published:	Wiley 2025-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/mi/7468297
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Modified Gegen Qinlian Decoction Ameliorates DSS-Induced Ulcerative Colitis in Mice by Inhibiting Ferroptosis via Nrf2/GPX4 Pathway
by: Jinke Huang, et al.
Published: (2024-01-01)

Effect of Gegen Qinlian Decoction on Cardiac Gene Expression in Diabetic Mice
by: Jing Han, et al.
Published: (2017-01-01)

Gegen Qinlian Decoction Attenuates Colitis-Associated Colorectal Cancer via Suppressing TLR4 Signaling Pathway Based on Network Pharmacology and In Vivo/In Vitro Experimental Validation
by: Yaoyao Xu, et al.
Published: (2024-12-01)

Phillyrin ameliorates DSS-induced colitis in mice via modulating the gut microbiota and inhibiting the NF-κB/MLCK pathway
by: Tong Li, et al.
Published: (2025-02-01)

Jiaweishaoyao Decoction Alleviates DSS-Induced Ulcerative Colitis via Inhibiting Inflammation
by: Huixia Qiao, et al.
Published: (2020-01-01)

Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway
by: Yunpeng Lou, et al.
Published: (2025-01-01)

Yunvjian decoction attenuates lipopolysaccharide-induced acute lung injury by inhibiting NF-κB/NLRP3 pathway and pyroptosis
by: Fanxuan Zhang, et al.
Published: (2025-01-01)

Preserved egg white alleviates DSS-induced colitis in mice through the reduction of oxidative stress, modulation of infl ammatory cytokines, NF-κB, MAPK and gut microbiota composition
by: Lingyu Li, et al.
Published: (2023-01-01)

CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway
by: Tianxin Geng, et al.
Published: (2020-01-01)

NRF2 Exerts Anti-Inflammatory Effects in LPS-Induced gEECs by Inhibiting the Activation of the NF-κB
by: Hongchu Bao, et al.
Published: (2021-01-01)

SPHK1 enhances olaparib resistance in ovarian cancer through the NFκB/NRF2/ferroptosis pathway
by: Kai Teng, et al.
Published: (2025-01-01)

WKB ameliorates DSS-induced colitis through inhibiting enteric glial cells activation and altering the intestinal microbiota
by: Qi Sun, et al.
Published: (2025-01-01)

Modified citrus pectin ameliorates methotrexate-induced hepatic and pulmonary toxicity: role of Nrf2, galectin-3/TLR-4/NF-κB/TNF-α and TGF-β signaling pathways
by: Randa Ismail, et al.
Published: (2025-01-01)

Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma
by: Yaqin Chen, et al.
Published: (2021-01-01)

Curcumin and α/β-Adrenergic Antagonists Cotreatment Reverse Liver Cirrhosis in Hamsters: Participation of Nrf-2 and NF-κB
by: José Roberto Macías-Pérez, et al.
Published: (2019-01-01)

Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion Injury via HMGB1/TLR/NF-κB Pathway
by: Kun Liu, et al.
Published: (2019-01-01)

Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain
by: Chae-Jeong Lee, et al.
Published: (2025-01-01)

The Nrf-2/HO-1 Signaling Axis: A Ray of Hope in Cardiovascular Diseases
by: Xueyan Zhang, et al.
Published: (2020-01-01)

Abatement by Alhagi maurorum of lead-induced nephrotoxicity in rats: emphasis on Nrf2/HO-1
by: Mardi M. Algandaby
Published: (2025-01-01)

Inhibition of NF-κB/IL-33/ST2 Axis Ameliorates Acute Bronchiolitis Induced by Respiratory Syncytial Virus
by: Liwen Zhang, et al.
Published: (2021-01-01)

Dietary Nannochloropsis oculata ameliorates lead acetate induced reproductive toxicity in Barki rams: NF-κB and cytokines pathways
by: Doaa H. Elsayed, et al.
Published: (2025-01-01)

Melatonin Reduces Inflammatory Injury Through Inhibiting NF-κB Activation in Rats With Colitis
by: Jun-Hua Li, et al.
Published: (2005-01-01)

Homoharringtonine Attenuates Dextran Sulfate Sodium-Induced Colitis by Inhibiting NF-κB Signaling
by: Jiangrui Liu, et al.
Published: (2022-01-01)

The role of NF-κB in diabetic cardiomyopathy
by: Huang-Jun Liu, et al.
Published: (2024-12-01)

Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB
by: Xianshe Meng, et al.
Published: (2024-01-01)

Donkey whey proteins ameliorate dextran sulfate sodium-induced ulcerative colitis in mice by downregulating the S100A8-TRAF6-NF-κB axis-mediated inflammatory response
by: Mohan Li, et al.
Published: (2023-09-01)

Curcumin Targeting NF-κB/Ubiquitin-Proteasome-System Axis Ameliorates Muscle Atrophy in Triple-Negative Breast Cancer Cachexia Mice
by: Jin Zhang, et al.
Published: (2022-01-01)

Corrigendum to “Irbesartan Ameliorates Diabetic Nephropathy by Suppressing the RANKL-RANK-NF-κB Pathway in Type 2 Diabetic db/db Mice”
by: Xiao-Wen Chen, et al.
Published: (2016-01-01)

Angelica acutiloba Kitagawa Extract Attenuates DSS-Induced Murine Colitis
by: Jong-Chan Jang, et al.
Published: (2016-01-01)

NF-κB Signaling in the Brain of Autistic Subjects
by: Mazhar Malik, et al.
Published: (2011-01-01)

Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability
by: Lipeng Dong, et al.
Published: (2013-01-01)

Influence of Rosiglitazone on the Expression of PPARγ, NF-κB, and TNF-α in Rat Model of Ulcerative Colitis
by: Jing-Wei Mao, et al.
Published: (2012-01-01)

Evaluation of the Effects of Different Bacteroides vulgatus Strains against DSS-Induced Colitis
by: Sijia Li, et al.
Published: (2021-01-01)

Stachyose modulates gut microbiota and alleviates DSS-induced ulcerative colitis in mice
by: Chen Wang, et al.
Published: (2023-11-01)

Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbiome
by: Wang H, et al.
Published: (2025-02-01)

Exploration of the Potential Mechanisms of Wumei Pill for the Treatment of Ulcerative Colitis by Network Pharmacology
by: Jinke Huang, et al.
Published: (2021-01-01)

NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis
by: Shin Maeda
Published: (2010-01-01)

Erratum to “NF-κB Signaling in the Brain of Autistic Subjects”
by: Mazhar Malik, et al.
Published: (2013-01-01)

Amelioration of Coagulation Disorders and Inflammation by Hydrogen-Rich Solution Reduces Intestinal Ischemia/Reperfusion Injury in Rats through NF-κB/NLRP3 Pathway
by: Ling Yang, et al.
Published: (2020-01-01)

Dapagliflozin inhibits ferroptosis to improve chronic heart failure by regulating Nrf2/HO-1/GPX4 signaling pathway.
by: Jing Zhang, et al.
Published: (2025-01-01)