A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus
Background. Sevoflurane is rarely used for the treatment of status asthmaticus. We report a case of sevoflurane hepatotoxicity in pregnancy with presentation similar to HELLP syndrome. Case. A G2P1001 at 23 weeks in status asthmaticus presented with pCO2 > 130 and pH < 7. She was nonresponsive...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2017/3547242 |
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| author | Jessica Parrott Mitch Tener Katie Dennis Matthew Sharpe Cecily Clark-Ganheart |
| author_facet | Jessica Parrott Mitch Tener Katie Dennis Matthew Sharpe Cecily Clark-Ganheart |
| author_sort | Jessica Parrott |
| collection | DOAJ |
| description | Background. Sevoflurane is rarely used for the treatment of status asthmaticus. We report a case of sevoflurane hepatotoxicity in pregnancy with presentation similar to HELLP syndrome. Case. A G2P1001 at 23 weeks in status asthmaticus presented with pCO2 > 130 and pH < 7. She was nonresponsive to traditional therapy. Sevoflurane was added for a 24 hr period. Respiratory status improved. Extubation occurred on day 12. Workup for preeclampsia spectrum disorders occurred due to maternal hypertension. Given the atypical presentation and hepatotoxicity, a liver biopsy was performed. Histologic features suggested drug induced hepatic injury. Liver function subsequently normalized. She delivered a term neonate without short-term complications. Conclusion. The use of sevoflurane is a treatment option of status asthmaticus during pregnancy. Providers should be aware of the potential for hepatotoxicity. |
| format | Article |
| id | doaj-art-0297f2d3c6914c5b8a589b912a65bd9e |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-0297f2d3c6914c5b8a589b912a65bd9e2025-02-03T01:02:55ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922017-01-01201710.1155/2017/35472423547242A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status AsthmaticusJessica Parrott0Mitch Tener1Katie Dennis2Matthew Sharpe3Cecily Clark-Ganheart4Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USADepartment of Pulmonary and Critical Care Medicine, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USADepartment of Pathology and Laboratory Medicine, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USADepartment of Pulmonary and Critical Care Medicine, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USADivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USABackground. Sevoflurane is rarely used for the treatment of status asthmaticus. We report a case of sevoflurane hepatotoxicity in pregnancy with presentation similar to HELLP syndrome. Case. A G2P1001 at 23 weeks in status asthmaticus presented with pCO2 > 130 and pH < 7. She was nonresponsive to traditional therapy. Sevoflurane was added for a 24 hr period. Respiratory status improved. Extubation occurred on day 12. Workup for preeclampsia spectrum disorders occurred due to maternal hypertension. Given the atypical presentation and hepatotoxicity, a liver biopsy was performed. Histologic features suggested drug induced hepatic injury. Liver function subsequently normalized. She delivered a term neonate without short-term complications. Conclusion. The use of sevoflurane is a treatment option of status asthmaticus during pregnancy. Providers should be aware of the potential for hepatotoxicity.http://dx.doi.org/10.1155/2017/3547242 |
| spellingShingle | Jessica Parrott Mitch Tener Katie Dennis Matthew Sharpe Cecily Clark-Ganheart A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus Case Reports in Obstetrics and Gynecology |
| title | A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus |
| title_full | A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus |
| title_fullStr | A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus |
| title_full_unstemmed | A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus |
| title_short | A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus |
| title_sort | case of sevoflurane use during pregnancy in the management of persistent status asthmaticus |
| url | http://dx.doi.org/10.1155/2017/3547242 |
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