Targeting acid ceramidase enhances antitumor immune response in colorectal cancer

Targeting acid ceramidase enhances antitumor immune response in colorectal cancer

Introduction: Acid ceramidase (hereafter referred as ASAH1) is an enzyme in sphingolipid metabolism that converts pro-survival ceramide into sphingosine. ASAH1 has been shown to be overexpressed in certain cancers. However, the role of ASAH1 in colorectal cancer still remain elusive. Objective: The...

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Main Authors: Yadu Vijayan, Shirley James, Arun Viswanathan, Jayasekharan S Aparna, Anu Bindu, Narayanan N Namitha, Devasena Anantharaman, Manendra Babu Lankadasari, Kuzhuvelil B Harikumar
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Advanced Research
Subjects:
Colorectal cancer
Acid ceramidase
LCL-521
Checkpoint inhibitor
Immunological cell death
T cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123223004034
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