Interleukin 24 Promotes Mitochondrial Dysfunction, Glucose Regulation, and Apoptosis by Inactivating Glycogen Synthase Kinase 3 Beta in Human Prostate Cancer Cells

Interleukin 24 Promotes Mitochondrial Dysfunction, Glucose Regulation, and Apoptosis by Inactivating Glycogen Synthase Kinase 3 Beta in Human Prostate Cancer Cells

Interleukin 24 (IL-24) is a tumor-suppressing protein currently in clinical trials. We previously demonstrated that IL-24 leads to apoptosis in cancer cells through protein kinase A (PKA) activation in human breast cancer cells. To better understand the mechanism by which IL-24 induces apoptosis, we...

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Bibliographic Details
Main Authors: Anastassiya Kim, Sual Lopez, Simira Smith, Alphons Sony, Jennifer Abreu, Columba de la Parra, Moira Sauane
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Cells
Subjects:
glycogen synthase kinase-3 beta
protein kinase A
Interleukin 24
mitochondria dysfunction
p38 MAPK
glucose
Online Access:https://www.mdpi.com/2073-4409/14/5/357
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