Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional Study
Background. The risk of cognitive impairment in patients with atrial fibrillation is significantly increased. Its occurrence may be related to blood hypercoagulable state and immune inflammatory reaction. Platelets can mediate immune inflammatory response, but there is no evidence about the relation...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2021/9039610 |
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| author | Dandan Sun Quanliang Wang Jie Kang Jie Zhou Ruijuan Qian Wenqing Wang Haichen Wang Qingyun Zhang |
| author_facet | Dandan Sun Quanliang Wang Jie Kang Jie Zhou Ruijuan Qian Wenqing Wang Haichen Wang Qingyun Zhang |
| author_sort | Dandan Sun |
| collection | DOAJ |
| description | Background. The risk of cognitive impairment in patients with atrial fibrillation is significantly increased. Its occurrence may be related to blood hypercoagulable state and immune inflammatory reaction. Platelets can mediate immune inflammatory response, but there is no evidence about the relationship between platelet count and cognitive function in patients with atrial fibrillation. Purpose. To explore whether there is a certain correlation between platelet count and cognitive function in patients with atrial fibrillation. Methods. A cross-sectional study was conducted in a single center in China, including 254 patients with atrial fibrillation. Cognitive function assessment and clinical and laboratory examinations were performed on all participants. After adjusting the related confounding factors, the relationship between platelet count and cognitive function was analyzed. Results. A total of 254 subjects with an average age of 59.71 ± 11.14 years were included. The average platelet count was 208.15 ± 68.30, and the average score of cognitive function was 19.29 ± 6.78. Result of fully adjusted binary logistic regression showed platelet count was negatively associated with the cognitive function score after adjusting confounders (hazard ratio (HR) = 0.000, 95%CI −0.01, 0.01). A nonlinear relationship was detected between platelet count and the cognitive function score, whose point was 230. The effect sizes and the confidence intervals of the left and right sides of the inflection point were 0.03 (0.01–0.05, P for nonlinearity = 0.011) and −0.03 (−0.05–0.00, P for nonlinearity = 0.023), respectively. Conclusion. Platelets have a nonlinear relationship with cognitive function in patients with atrial fibrillation. This finding suggests that, in patients with atrial fibrillation, platelets should be maintained at about 230. |
| format | Article |
| id | doaj-art-0248a0314a8445daa6bcf2135f2fb5f9 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-0248a0314a8445daa6bcf2135f2fb5f92025-02-03T06:07:39ZengWileyCardiology Research and Practice2090-80162090-05972021-01-01202110.1155/2021/90396109039610Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional StudyDandan Sun0Quanliang Wang1Jie Kang2Jie Zhou3Ruijuan Qian4Wenqing Wang5Haichen Wang6Qingyun Zhang7Department of Cardiology of Affiliated Hospital, Jining Medical University, 89# Guhuai Road, Rencheng District, Jining City 272000, Shandong Province, ChinaDepartment of Cardiology of Affiliated Hospital, Jining Medical University, 89# Guhuai Road, Rencheng District, Jining City 272000, Shandong Province, ChinaDepartment of Cardiology of Affiliated Hospital, Jining Medical University, 89# Guhuai Road, Rencheng District, Jining City 272000, Shandong Province, ChinaDepartment of Cardiology of Affiliated Hospital, Jining Medical University, 89# Guhuai Road, Rencheng District, Jining City 272000, Shandong Province, ChinaDepartment of Cardiology of Affiliated Hospital, Jining Medical University, 89# Guhuai Road, Rencheng District, Jining City 272000, Shandong Province, ChinaDepartment of Cardiology of Affiliated Hospital, Jining Medical University, 89# Guhuai Road, Rencheng District, Jining City 272000, Shandong Province, ChinaDepartment of Cardiology of Affiliated Hospital, Jining Medical University, 89# Guhuai Road, Rencheng District, Jining City 272000, Shandong Province, ChinaDepartment of Cardiology of Affiliated Hospital, Jining Medical University, 89# Guhuai Road, Rencheng District, Jining City 272000, Shandong Province, ChinaBackground. The risk of cognitive impairment in patients with atrial fibrillation is significantly increased. Its occurrence may be related to blood hypercoagulable state and immune inflammatory reaction. Platelets can mediate immune inflammatory response, but there is no evidence about the relationship between platelet count and cognitive function in patients with atrial fibrillation. Purpose. To explore whether there is a certain correlation between platelet count and cognitive function in patients with atrial fibrillation. Methods. A cross-sectional study was conducted in a single center in China, including 254 patients with atrial fibrillation. Cognitive function assessment and clinical and laboratory examinations were performed on all participants. After adjusting the related confounding factors, the relationship between platelet count and cognitive function was analyzed. Results. A total of 254 subjects with an average age of 59.71 ± 11.14 years were included. The average platelet count was 208.15 ± 68.30, and the average score of cognitive function was 19.29 ± 6.78. Result of fully adjusted binary logistic regression showed platelet count was negatively associated with the cognitive function score after adjusting confounders (hazard ratio (HR) = 0.000, 95%CI −0.01, 0.01). A nonlinear relationship was detected between platelet count and the cognitive function score, whose point was 230. The effect sizes and the confidence intervals of the left and right sides of the inflection point were 0.03 (0.01–0.05, P for nonlinearity = 0.011) and −0.03 (−0.05–0.00, P for nonlinearity = 0.023), respectively. Conclusion. Platelets have a nonlinear relationship with cognitive function in patients with atrial fibrillation. This finding suggests that, in patients with atrial fibrillation, platelets should be maintained at about 230.http://dx.doi.org/10.1155/2021/9039610 |
| spellingShingle | Dandan Sun Quanliang Wang Jie Kang Jie Zhou Ruijuan Qian Wenqing Wang Haichen Wang Qingyun Zhang Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional Study Cardiology Research and Practice |
| title | Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional Study |
| title_full | Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional Study |
| title_fullStr | Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional Study |
| title_full_unstemmed | Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional Study |
| title_short | Correlation between Serum Platelet Count and Cognitive Function in Patients with Atrial Fibrillation: A Cross-Sectional Study |
| title_sort | correlation between serum platelet count and cognitive function in patients with atrial fibrillation a cross sectional study |
| url | http://dx.doi.org/10.1155/2021/9039610 |
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