Host Epithelial Interactions with Helicobacter Pylori: A Role for Disrupted Gastric Barrier Function in the Clinical Outcome of Infection?
Infection of the human stomach with Helicobacter pylori may develop into gastritis, ulceration, adenocarcinoma and mucosal lymphomas. The pathogenic mechanisms that determine the clinical outcome from this microbial-epithelial interaction remain poorly understood. An increasing number of reports sug...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2005/940213 |
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| _version_ | 1832556654797783040 |
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| author | Andre G Buret Jason P Fedwick Andrew N Flynn |
| author_facet | Andre G Buret Jason P Fedwick Andrew N Flynn |
| author_sort | Andre G Buret |
| collection | DOAJ |
| description | Infection of the human stomach with Helicobacter pylori may develop into gastritis, ulceration, adenocarcinoma and mucosal lymphomas. The pathogenic mechanisms that determine the clinical outcome from this microbial-epithelial interaction remain poorly understood. An increasing number of reports suggests that disruptions of epithelial barrier function may contribute to pathology and postinfectious complications in a variety of gastrointestinal infections. The aim of this review is to critically discuss the implications of H pylori persistence on gastric disease, with emphasis on the role of myosin light chain kinase, claudins and matrix metalloproteinases in gastric permeability defects, and their contribution to the development of cancer. These mechanisms and the associated signalling events may represent novel therapeutic targets to control disease processes induced by H pylori, a microbial pathogen that colonizes the stomach of over 50% of the human population. |
| format | Article |
| id | doaj-art-02175c4b6da744bab33f4f7a9e3030a5 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-02175c4b6da744bab33f4f7a9e3030a52025-02-03T05:44:39ZengWileyCanadian Journal of Gastroenterology0835-79002005-01-0119954355210.1155/2005/940213Host Epithelial Interactions with Helicobacter Pylori: A Role for Disrupted Gastric Barrier Function in the Clinical Outcome of Infection?Andre G Buret0Jason P Fedwick1Andrew N Flynn2Department of Biological Sciences and Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta, CanadaDepartment of Biological Sciences and Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta, CanadaDepartment of Biological Sciences and Mucosal Inflammation Research Group, University of Calgary, Calgary, Alberta, CanadaInfection of the human stomach with Helicobacter pylori may develop into gastritis, ulceration, adenocarcinoma and mucosal lymphomas. The pathogenic mechanisms that determine the clinical outcome from this microbial-epithelial interaction remain poorly understood. An increasing number of reports suggests that disruptions of epithelial barrier function may contribute to pathology and postinfectious complications in a variety of gastrointestinal infections. The aim of this review is to critically discuss the implications of H pylori persistence on gastric disease, with emphasis on the role of myosin light chain kinase, claudins and matrix metalloproteinases in gastric permeability defects, and their contribution to the development of cancer. These mechanisms and the associated signalling events may represent novel therapeutic targets to control disease processes induced by H pylori, a microbial pathogen that colonizes the stomach of over 50% of the human population.http://dx.doi.org/10.1155/2005/940213 |
| spellingShingle | Andre G Buret Jason P Fedwick Andrew N Flynn Host Epithelial Interactions with Helicobacter Pylori: A Role for Disrupted Gastric Barrier Function in the Clinical Outcome of Infection? Canadian Journal of Gastroenterology |
| title | Host Epithelial Interactions with Helicobacter Pylori: A Role for Disrupted Gastric Barrier Function in the Clinical Outcome of Infection? |
| title_full | Host Epithelial Interactions with Helicobacter Pylori: A Role for Disrupted Gastric Barrier Function in the Clinical Outcome of Infection? |
| title_fullStr | Host Epithelial Interactions with Helicobacter Pylori: A Role for Disrupted Gastric Barrier Function in the Clinical Outcome of Infection? |
| title_full_unstemmed | Host Epithelial Interactions with Helicobacter Pylori: A Role for Disrupted Gastric Barrier Function in the Clinical Outcome of Infection? |
| title_short | Host Epithelial Interactions with Helicobacter Pylori: A Role for Disrupted Gastric Barrier Function in the Clinical Outcome of Infection? |
| title_sort | host epithelial interactions with helicobacter pylori a role for disrupted gastric barrier function in the clinical outcome of infection |
| url | http://dx.doi.org/10.1155/2005/940213 |
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