COMPUTER ANALYSIS OF DATA ON GENE EXPRESSION IN BRAIN CELLS OBTAINED BY MICROARRAY TESTS AND HIGH-THROUGHPUT SEQUENCING
The scope of neurobiological studies has been greatly expanded in the last years. It is accompanied by accumulation of a huge body of experimental data on the structure, function and evolution of the nervous system at different hierarchical levels of its organization. High-throughput sequencing tech...
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| Format: | Article |
| Language: | English |
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Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2015-01-01
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| Series: | Вавиловский журнал генетики и селекции |
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| Online Access: | https://vavilov.elpub.ru/jour/article/view/187 |
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| author | I. V. Medvedeva O. V. Vishnevsky N. S. Safronova O. S. Kozhevnikova M. A. Genaev A. V. Kochetov D. A. Afonnikov Y. L. Orlov |
| author_facet | I. V. Medvedeva O. V. Vishnevsky N. S. Safronova O. S. Kozhevnikova M. A. Genaev A. V. Kochetov D. A. Afonnikov Y. L. Orlov |
| author_sort | I. V. Medvedeva |
| collection | DOAJ |
| description | The scope of neurobiological studies has been greatly expanded in the last years. It is accompanied by accumulation of a huge body of experimental data on the structure, function and evolution of the nervous system at different hierarchical levels of its organization. High-throughput sequencing technologies and microarray tests permit the expression of thousands of genes to be analyzed with regard to cell location in the brain. Methods of gene expression analysis are briefly reviewed in the context of brain research. We have analyzed specific features of genes differentially expressed in brain cells. Some genes overexpressed in brain tissues are associated with neurological diseases. The numbers of exons and active transcripts in genes differentially expressed in different organs are considered. Statistically significant difference in such parameters is shown for genes intensely expressed in the brain and other organs. Examples of such differentially expressed genes associated with neurological deceases are presented. |
| format | Article |
| id | doaj-art-01d75598a7ab4b95a0f1036f7d26a200 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-01d75598a7ab4b95a0f1036f7d26a2002025-02-01T09:58:00ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592015-01-01174/1629638171COMPUTER ANALYSIS OF DATA ON GENE EXPRESSION IN BRAIN CELLS OBTAINED BY MICROARRAY TESTS AND HIGH-THROUGHPUT SEQUENCINGI. V. Medvedeva0O. V. Vishnevsky1N. S. Safronova2O. S. Kozhevnikova3M. A. Genaev4A. V. Kochetov5D. A. Afonnikov6Y. L. Orlov7Institute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaInstitute of Cytology and Genetics SB RAS, Novosibirsk, RussiaThe scope of neurobiological studies has been greatly expanded in the last years. It is accompanied by accumulation of a huge body of experimental data on the structure, function and evolution of the nervous system at different hierarchical levels of its organization. High-throughput sequencing technologies and microarray tests permit the expression of thousands of genes to be analyzed with regard to cell location in the brain. Methods of gene expression analysis are briefly reviewed in the context of brain research. We have analyzed specific features of genes differentially expressed in brain cells. Some genes overexpressed in brain tissues are associated with neurological diseases. The numbers of exons and active transcripts in genes differentially expressed in different organs are considered. Statistically significant difference in such parameters is shown for genes intensely expressed in the brain and other organs. Examples of such differentially expressed genes associated with neurological deceases are presented.https://vavilov.elpub.ru/jour/article/view/187bioinformaticsbraingene expressionmicroarraysequencing |
| spellingShingle | I. V. Medvedeva O. V. Vishnevsky N. S. Safronova O. S. Kozhevnikova M. A. Genaev A. V. Kochetov D. A. Afonnikov Y. L. Orlov COMPUTER ANALYSIS OF DATA ON GENE EXPRESSION IN BRAIN CELLS OBTAINED BY MICROARRAY TESTS AND HIGH-THROUGHPUT SEQUENCING Вавиловский журнал генетики и селекции bioinformatics brain gene expression microarray sequencing |
| title | COMPUTER ANALYSIS OF DATA ON GENE EXPRESSION IN BRAIN CELLS OBTAINED BY MICROARRAY TESTS AND HIGH-THROUGHPUT SEQUENCING |
| title_full | COMPUTER ANALYSIS OF DATA ON GENE EXPRESSION IN BRAIN CELLS OBTAINED BY MICROARRAY TESTS AND HIGH-THROUGHPUT SEQUENCING |
| title_fullStr | COMPUTER ANALYSIS OF DATA ON GENE EXPRESSION IN BRAIN CELLS OBTAINED BY MICROARRAY TESTS AND HIGH-THROUGHPUT SEQUENCING |
| title_full_unstemmed | COMPUTER ANALYSIS OF DATA ON GENE EXPRESSION IN BRAIN CELLS OBTAINED BY MICROARRAY TESTS AND HIGH-THROUGHPUT SEQUENCING |
| title_short | COMPUTER ANALYSIS OF DATA ON GENE EXPRESSION IN BRAIN CELLS OBTAINED BY MICROARRAY TESTS AND HIGH-THROUGHPUT SEQUENCING |
| title_sort | computer analysis of data on gene expression in brain cells obtained by microarray tests and high throughput sequencing |
| topic | bioinformatics brain gene expression microarray sequencing |
| url | https://vavilov.elpub.ru/jour/article/view/187 |
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