Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat Deposition
Pattern of fat distribution is a major determinant for metabolic homeostasis. As a depot of energy, the storage of triglycerides in adipose tissue contributes to the normal fat distribution. Decreased capacity of fat storage in adipose tissue may result in ectopic fat deposition in nonadipose tissue...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/418185 |
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| _version_ | 1832553307143405568 |
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| author | Lulu Liu Mei Mei Shumin Yang Qifu Li |
| author_facet | Lulu Liu Mei Mei Shumin Yang Qifu Li |
| author_sort | Lulu Liu |
| collection | DOAJ |
| description | Pattern of fat distribution is a major determinant for metabolic homeostasis. As a depot of energy, the storage of triglycerides in adipose tissue contributes to the normal fat distribution. Decreased capacity of fat storage in adipose tissue may result in ectopic fat deposition in nonadipose tissues such as liver, pancreas, and kidney. As a critical biomarker of metabolic complications, chronic low-grade inflammation may have the ability to affect the process of lipid accumulation and further lead to the disorder of fat distribution. In this review, we have collected the evidence linking inflammation with ectopic fat deposition to get a better understanding of the underlying mechanism, which may provide us with novel therapeutic strategies for metabolic disorders. |
| format | Article |
| id | doaj-art-01c2a3b1370c45a0b81fddf0a297856a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-01c2a3b1370c45a0b81fddf0a297856a2025-02-03T05:54:22ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/418185418185Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat DepositionLulu Liu0Mei Mei1Shumin Yang2Qifu Li3Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Street, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Street, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Street, Chongqing 400016, ChinaDepartment of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Street, Chongqing 400016, ChinaPattern of fat distribution is a major determinant for metabolic homeostasis. As a depot of energy, the storage of triglycerides in adipose tissue contributes to the normal fat distribution. Decreased capacity of fat storage in adipose tissue may result in ectopic fat deposition in nonadipose tissues such as liver, pancreas, and kidney. As a critical biomarker of metabolic complications, chronic low-grade inflammation may have the ability to affect the process of lipid accumulation and further lead to the disorder of fat distribution. In this review, we have collected the evidence linking inflammation with ectopic fat deposition to get a better understanding of the underlying mechanism, which may provide us with novel therapeutic strategies for metabolic disorders.http://dx.doi.org/10.1155/2014/418185 |
| spellingShingle | Lulu Liu Mei Mei Shumin Yang Qifu Li Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat Deposition Mediators of Inflammation |
| title | Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat Deposition |
| title_full | Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat Deposition |
| title_fullStr | Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat Deposition |
| title_full_unstemmed | Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat Deposition |
| title_short | Roles of Chronic Low-Grade Inflammation in the Development of Ectopic Fat Deposition |
| title_sort | roles of chronic low grade inflammation in the development of ectopic fat deposition |
| url | http://dx.doi.org/10.1155/2014/418185 |
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