Synthesis and Biological Activity of 3-Chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-one
Perimidine-1-acetic acid hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding azomethine (i.e. Schiff base) derivatives (2a-h) in good yield. Cyclocondensation of compounds (2a-h) with chloro acetyl chloride affords 3-chloro-1-(4-perimidine methylcarbonylam...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2009/457168 |
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| author | Dinesh R. Panchasara Subhash Pande |
| author_facet | Dinesh R. Panchasara Subhash Pande |
| author_sort | Dinesh R. Panchasara |
| collection | DOAJ |
| description | Perimidine-1-acetic acid hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding azomethine (i.e. Schiff base) derivatives (2a-h) in good yield. Cyclocondensation of compounds (2a-h) with chloro acetyl chloride affords 3-chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-ones (3a-h). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities. |
| format | Article |
| id | doaj-art-0182e17858ab48ca9cfe0df7a33a04f1 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-0182e17858ab48ca9cfe0df7a33a04f12025-02-03T05:51:59ZengWileyE-Journal of Chemistry0973-49452090-98102009-01-016S1S91S9610.1155/2009/457168Synthesis and Biological Activity of 3-Chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-oneDinesh R. Panchasara0Subhash Pande1Department of Chemistry, Govt. Geetanjali P.G. Girls College, Bhopal, IndiaDepartment of Chemistry, Govt. Geetanjali P.G. Girls College, Bhopal, IndiaPerimidine-1-acetic acid hydrazide (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding azomethine (i.e. Schiff base) derivatives (2a-h) in good yield. Cyclocondensation of compounds (2a-h) with chloro acetyl chloride affords 3-chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-ones (3a-h). The structures of these compounds were established on the basis of analytical and spectral data. The newly synthesized compounds were evaluated for their antibacterial and antifungal activities.http://dx.doi.org/10.1155/2009/457168 |
| spellingShingle | Dinesh R. Panchasara Subhash Pande Synthesis and Biological Activity of 3-Chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-one E-Journal of Chemistry |
| title | Synthesis and Biological Activity of 3-Chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-one |
| title_full | Synthesis and Biological Activity of 3-Chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-one |
| title_fullStr | Synthesis and Biological Activity of 3-Chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-one |
| title_full_unstemmed | Synthesis and Biological Activity of 3-Chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-one |
| title_short | Synthesis and Biological Activity of 3-Chloro-1-(4-perimidine methylcarbonylamino)-4-phenyl-azetidin-2-one |
| title_sort | synthesis and biological activity of 3 chloro 1 4 perimidine methylcarbonylamino 4 phenyl azetidin 2 one |
| url | http://dx.doi.org/10.1155/2009/457168 |
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