Activation of PIEZO1 Attenuates Kidney Cystogenesis In Vitro and Ex Vivo

Activation of PIEZO1 Attenuates Kidney Cystogenesis In Vitro and Ex Vivo

Key Points. PIEZO1 activation reduces cystogenesis: Yoda1 activates PIEZO1, raising calcium and lowering cAMP, reducing cyst growth in autosomal dominant polycystic kidney disease models. Context-dependent role of PIEZO1: PIEZO1 knockout in mice with or without polycystic kidneys does not affect cys...

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Bibliographic Details
Main Authors: Qingfeng Fan, Mohamad Hadla, Zack Peterson, Grace Nelson, Hong Ye, Xiaofang Wang, Jean Marc Mardirossian, Peter C. Harris, Seth L. Alper, Y.S. Prakash, Arthur Beyder, Vicente E. Torres, Fouad T. Chebib
Format: Article
Language:English
Published: Wolters Kluwer - Lippincott Williams & Wilkins 2024-11-01
Series:Kidney360
Online Access:http://journals.lww.com/10.34067/KID.0000000598
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http://journals.lww.com/10.34067/KID.0000000598

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