Successful Neoadjuvant Therapy with Pembrolizumab Monotherapy for Advanced Ascending Colon Cancer
Immune checkpoint inhibitors have emerged as an effective standard of care for deficient mismatch repair (dMMR)/high microsatellite instability (MSI-H) metastatic colorectal cancer (CRC). However, the role of immunotherapy in the neoadjuvant setting remains uncertain. We report a patient with advanc...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-07-01
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| Series: | Journal of Cancer Research and Practice |
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| Online Access: | https://journals.lww.com/10.4103/ejcrp.eJCRP-D-23-00005 |
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| author | Chien-Tzu Huang* Jeng-Shiun Du |
| author_facet | Chien-Tzu Huang* Jeng-Shiun Du |
| author_sort | Chien-Tzu Huang* |
| collection | DOAJ |
| description | Immune checkpoint inhibitors have emerged as an effective standard of care for deficient mismatch repair (dMMR)/high microsatellite instability (MSI-H) metastatic colorectal cancer (CRC). However, the role of immunotherapy in the neoadjuvant setting remains uncertain. We report a patient with advanced colon cancer who received curative surgery after successful treatment with pembrolizumab monotherapy. She remains in complete remission after 16 months following the first diagnosis without any immune-related adverse events. In conclusion, single-agent pembrolizumab has strong potential in neoadjuvant therapy for patients with dMMR/MSI-H advanced CRC. |
| format | Article |
| id | doaj-art-014e93cd044c430bb9c64c146858d83f |
| institution | Kabale University |
| issn | 2311-3006 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cancer Research and Practice |
| spelling | doaj-art-014e93cd044c430bb9c64c146858d83f2025-01-23T05:07:29ZengWolters Kluwer Medknow PublicationsJournal of Cancer Research and Practice2311-30062023-07-0110311812010.4103/ejcrp.eJCRP-D-23-00005Successful Neoadjuvant Therapy with Pembrolizumab Monotherapy for Advanced Ascending Colon CancerChien-Tzu Huang*Jeng-Shiun DuImmune checkpoint inhibitors have emerged as an effective standard of care for deficient mismatch repair (dMMR)/high microsatellite instability (MSI-H) metastatic colorectal cancer (CRC). However, the role of immunotherapy in the neoadjuvant setting remains uncertain. We report a patient with advanced colon cancer who received curative surgery after successful treatment with pembrolizumab monotherapy. She remains in complete remission after 16 months following the first diagnosis without any immune-related adverse events. In conclusion, single-agent pembrolizumab has strong potential in neoadjuvant therapy for patients with dMMR/MSI-H advanced CRC.https://journals.lww.com/10.4103/ejcrp.eJCRP-D-23-00005colorectal cancerdeficient mismatch repairimmune checkpoint inhibitormicrosatellite instabilitypembrolizumab |
| spellingShingle | Chien-Tzu Huang* Jeng-Shiun Du Successful Neoadjuvant Therapy with Pembrolizumab Monotherapy for Advanced Ascending Colon Cancer Journal of Cancer Research and Practice colorectal cancer deficient mismatch repair immune checkpoint inhibitor microsatellite instability pembrolizumab |
| title | Successful Neoadjuvant Therapy with Pembrolizumab Monotherapy for Advanced Ascending Colon Cancer |
| title_full | Successful Neoadjuvant Therapy with Pembrolizumab Monotherapy for Advanced Ascending Colon Cancer |
| title_fullStr | Successful Neoadjuvant Therapy with Pembrolizumab Monotherapy for Advanced Ascending Colon Cancer |
| title_full_unstemmed | Successful Neoadjuvant Therapy with Pembrolizumab Monotherapy for Advanced Ascending Colon Cancer |
| title_short | Successful Neoadjuvant Therapy with Pembrolizumab Monotherapy for Advanced Ascending Colon Cancer |
| title_sort | successful neoadjuvant therapy with pembrolizumab monotherapy for advanced ascending colon cancer |
| topic | colorectal cancer deficient mismatch repair immune checkpoint inhibitor microsatellite instability pembrolizumab |
| url | https://journals.lww.com/10.4103/ejcrp.eJCRP-D-23-00005 |
| work_keys_str_mv | AT chientzuhuang successfulneoadjuvanttherapywithpembrolizumabmonotherapyforadvancedascendingcoloncancer AT jengshiundu successfulneoadjuvanttherapywithpembrolizumabmonotherapyforadvancedascendingcoloncancer |