Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8.

Heparin modulates the endopeptidase activity of Leishmania mexicana cysteine protease cathepsin L-Like rCPB2.8.

<h4>Background</h4>Cysteine protease B is considered crucial for the survival and infectivity of the Leishmania in its human host. Several microorganism pathogens bind to the heparin-like glycosaminoglycans chains of proteoglycans at host-cell surface to promote their attachment and inte...

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Main Authors: Wagner A S Judice, Marcella A Manfredi, Gerson P Souza, Thiago M Sansevero, Paulo C Almeida, Cláudio S Shida, Tarsis F Gesteira, Luiz Juliano, Gareth D Westrop, Sanya J Sanderson, Graham H Coombs, Ivarne L S Tersariol
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0080153
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