Bone marrow-targeted thrombopoietin delivery via engineered platelet-derived vesicle-loaded dissolving microneedles for treating ionizing radiation-induced injury

Bone marrow-targeted thrombopoietin delivery via engineered platelet-derived vesicle-loaded dissolving microneedles for treating ionizing radiation-induced injury

Exposure to a nuclear accident or a radiological attack may cause serious death events due to hematopoietic acute radiation syndrome (H-ARS). While thrombopoietin (TPO) shows promise in mitigating myelosuppression, its clinical use is restricted due to high doses, strict schedules, and systemic toxi...

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Bibliographic Details
Main Authors: Zhenchao Ma, Yuntao Li, Jiawei Zhu, Sheng Qiu, Yingrong Chen, Hengbin Cao, Shuixin Yang, Xueli Jia, Lixia Huo, Qian Shi, Shunwen Han, Hao Chang, Xiang Yu
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Microneedle
Activated platelet-derived vesicles
Thrombopoietin
Ionizing radiation
Mitochondria
Hematopoietic stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425005502
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