<i>shp-2</i> gene knockout upregulates CAR-driven cytotoxicity of YT NK cells

<i>shp-2</i> gene knockout upregulates CAR-driven cytotoxicity of YT NK cells

In Russia, cancer is the second leading cause of death following cardiovascular diseases. Adoptive transfer of NK cells is a promising approach to fight cancer; however, for their successful use in cancer treatment, it is necessary to ensure their robust accumulation at tumor foci, provide resistanc...

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Bibliographic Details
Main Authors: V. G. Subrakova, S. V. Kulemzin, T. N. Belovezhets, A. N. Chikaev, N. A. Chikaev, O. A. Koval, A. A. Gorchakov, A. V. Taranin
Format: Article
Language:English
Published: Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2020-03-01
Series:Вавиловский журнал генетики и селекции
Subjects:
nk cells
crispr/cas9
car-nk
shp-2
Online Access:https://vavilov.elpub.ru/jour/article/view/2483
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