Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function
The principal function of skin is to form an effective barrier between the human body and its environment. Impaired barrier function represents a precondition for the development of skin diseases such as atopic dermatitis (AD), which is the most common inflammatory skin disease characterized by skin...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-06-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2024-0014 |
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| _version_ | 1832569023998459904 |
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| author | Vitek Mercedes Matjaž Mirjam Gosenca |
| author_facet | Vitek Mercedes Matjaž Mirjam Gosenca |
| author_sort | Vitek Mercedes |
| collection | DOAJ |
| description | The principal function of skin is to form an effective barrier between the human body and its environment. Impaired barrier function represents a precondition for the development of skin diseases such as atopic dermatitis (AD), which is the most common inflammatory skin disease characterized by skin barrier dysfunction. AD significantly affects patients’ quality of life, thus, there is a growing interest in the development of novel delivery systems that would improve therapeutic outcomes. Herein, eight novel lyotropic liquid crystals (LCCs) were investigated for the first time in a double-blind, interventional, before-after, single-group trial with healthy adult subjects and a twice-daily application regimen. LCCs consisted of constituents with skin regenerative properties and exhibited lamellar micro-structure, especially suitable for dermal application. The short- and long-term effects of LCCs on TEWL, SC hydration, erythema index, melanin index, and tolerability were determined and compared with baseline. LCCs with the highest oil content and lecithin/Tween 80 mixture stood out by providing a remarkable 2-fold reduction in TEWL values and showing the most distinctive decrease in skin erythema levels in both the short- and long-term exposure. Therefore, they exhibit great potential for clinical use as novel delivery systems for AD treatment, capable of repairing skin barrier function. |
| format | Article |
| id | doaj-art-00e5e4c28a7a4a709d44788f0c05bea1 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-00e5e4c28a7a4a709d44788f0c05bea12025-02-02T23:21:01ZengSciendoActa Pharmaceutica1846-95582024-06-0174230131310.2478/acph-2024-0014Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier functionVitek Mercedes0Matjaž Mirjam Gosenca11University of Ljubljana Faculty of Pharmacy, Department of Pharmaceutical Technology, 1000LjubljanaSlovenia1University of Ljubljana Faculty of Pharmacy, Department of Pharmaceutical Technology, 1000LjubljanaSloveniaThe principal function of skin is to form an effective barrier between the human body and its environment. Impaired barrier function represents a precondition for the development of skin diseases such as atopic dermatitis (AD), which is the most common inflammatory skin disease characterized by skin barrier dysfunction. AD significantly affects patients’ quality of life, thus, there is a growing interest in the development of novel delivery systems that would improve therapeutic outcomes. Herein, eight novel lyotropic liquid crystals (LCCs) were investigated for the first time in a double-blind, interventional, before-after, single-group trial with healthy adult subjects and a twice-daily application regimen. LCCs consisted of constituents with skin regenerative properties and exhibited lamellar micro-structure, especially suitable for dermal application. The short- and long-term effects of LCCs on TEWL, SC hydration, erythema index, melanin index, and tolerability were determined and compared with baseline. LCCs with the highest oil content and lecithin/Tween 80 mixture stood out by providing a remarkable 2-fold reduction in TEWL values and showing the most distinctive decrease in skin erythema levels in both the short- and long-term exposure. Therefore, they exhibit great potential for clinical use as novel delivery systems for AD treatment, capable of repairing skin barrier function.https://doi.org/10.2478/acph-2024-0014lamellar liquid crystalsatopic dermatitistransepidermal water lossstratum corneum hydrationerythema indexmelanin index |
| spellingShingle | Vitek Mercedes Matjaž Mirjam Gosenca Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function Acta Pharmaceutica lamellar liquid crystals atopic dermatitis transepidermal water loss stratum corneum hydration erythema index melanin index |
| title | Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function |
| title_full | Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function |
| title_fullStr | Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function |
| title_full_unstemmed | Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function |
| title_short | Clinical application of hempseed or flaxseed oil-based lyotropic liquid crystals: Evaluation of their impact on skin barrier function |
| title_sort | clinical application of hempseed or flaxseed oil based lyotropic liquid crystals evaluation of their impact on skin barrier function |
| topic | lamellar liquid crystals atopic dermatitis transepidermal water loss stratum corneum hydration erythema index melanin index |
| url | https://doi.org/10.2478/acph-2024-0014 |
| work_keys_str_mv | AT vitekmercedes clinicalapplicationofhempseedorflaxseedoilbasedlyotropicliquidcrystalsevaluationoftheirimpactonskinbarrierfunction AT matjazmirjamgosenca clinicalapplicationofhempseedorflaxseedoilbasedlyotropicliquidcrystalsevaluationoftheirimpactonskinbarrierfunction |