Outer membrane tube formation by Francisella novicida involves extensive envelope modifications and is linked with type VI secretion and alterations to the host phagosomal membrane

Outer membrane tube formation by Francisella novicida involves extensive envelope modifications and is linked with type VI secretion and alterations to the host phagosomal membrane

ABSTRACT Francisella tularensis is a gram-negative, intracellular pathogen that causes the zoonotic disease tularemia. Due to its ease of dissemination and high lethality, F. tularensis is classified as a tier 1 select agent with potential for misuse as a bioweapon. The mechanisms by which Francisel...

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Bibliographic Details
Main Authors: Maheen Rashid, Shoichi Tachiyama, Shiwei Zhu, Hang Zhao, William D. McCaig, Jingchuan Sun, Huilin Li, Jun Liu, David G. Thanassi
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
Francisella
outer membrane vesicles
bacterial pathogens
type VI secretion system
macrophage infection
Online Access:https://journals.asm.org/doi/10.1128/mbio.01060-25
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https://journals.asm.org/doi/10.1128/mbio.01060-25

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