Epithelial-to-mesenchymal transition is an active process in the large airways of patients with asthma-COPD overlap and partially abrogated by inhaled corticosteroid treatment: a bronchoscopy endobronchial biopsy study

Epithelial-to-mesenchymal transition is an active process in the large airways of patients with asthma-COPD overlap and partially abrogated by inhaled corticosteroid treatment: a bronchoscopy endobronchial biopsy study

IntroductionAsthma and chronic obstructive pulmonary disease (COPD) overlap (ACO) is a term used to describe a patient with coexisting clinical features of asthma and COPD. We have previously reported that epithelial to mesenchymal transition (EMT) is active in the lungs of patients with COPD howeve...

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Main Authors: Surajit Dey, Wenying Lu, Prabuddha S. Pathinayake, Maddison Waters, Greg Haug, Josie Larby, Heinrich C. Weber, Peter A. B. Wark, Mathew Suji Eapen, Sukhwinder Singh Sohal
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
asthma-COPD overlap (ACO)
COPD - chronic obstructive pulmonary disease
smoking
fibrosis
ICS - inhaled corticosteroids
histopathology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531279/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1531279/full

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