PEGylated Elesclomol@Cu(Ⅱ)-based Metal‒organic framework with effective nanozyme performance and cuproptosis induction efficacy for enhanced PD-L1-based immunotherapy

PEGylated Elesclomol@Cu(Ⅱ)-based Metal‒organic framework with effective nanozyme performance and cuproptosis induction efficacy for enhanced PD-L1-based immunotherapy

Nanozymes constitute a promising treatment strategy for antitumor therapy. However, the catalytic function of metal‒organic framework (MOF)-based nanozymes during cuproptosis remains unclear. In this study, a Cu(Ⅱ)-based MOF nanocomposite loaded with the copper ionophore elesclomol and surface modif...

Full description

Saved in:
Bibliographic Details
Main Authors: Xufeng Lu, Wenhai Deng, Shuaibin Wang, Shengsheng Zhao, Bingzi Zhu, Binglong Bai, Yiwen Mao, Ji Lin, Yongdong Yi, Zuoliang Xie, Xiang Wang, Yongyong Lu, Xiufeng Huang, Tao You, Xiaolei Chen, Weijian Sun, Xian Shen
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Materials Today Bio
Subjects:
Cu(Ⅱ)-MOF
Nanozyme
Cuproptosis
Breast cancer
Anti-PD-L1 antibody
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424003788
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2590006424003788

Similar Items